List of inclusion and exclusion criteria
| Inclusion criteria | Exclusion criteria | |
| Participants | Approved donors (age 18 years and greater) who underwent unilateral nephrectomy as selected candidates who met criteria for living kidney donation with or without hypertension | Participants who underwent unilateral nephrectomy other than for kidney donation Children and adolescents with solitary kidney after unilateral nephrectomy Pregnant living kidney donors of living donor kidneys will be excluded. Studies that do not report that consent was obtained will be excluded. Studies that do not report having obtained ethics approval will be excluded. Studies that report on executed prisoners or any other marginalised population will be excluded. |
| Intervention | Approved donors (age 18 years and older) who underwent nephrectomy who met criteria for kidney donation with hypertension | |
| Comparator | Approved donors (age 18 years and older) who underwent nephrectomy who met criteria for kidney donation without hypertension Comparable non-donors and general population with hypertension | None |
| Outcome | Donor Outcomes: Survival, major adverse cardiovascular events, eGFR 45 mL/min or less, development of end-stage kidney disease | None |
| Study Design | Prospective studies (cohort, case–control, case series, before-and-after studies, randomised controlled trials) and retrospective studies to be included in the primary analysis Articles reported in English | Paediatric and non-human studies Narrative reviews Mathematical modelling reports Duplicates Substudies of previously published trials Abstracts, conference proceedings |
eGFR, estimated glomerular filtration rate.