Schedule of assessments
| Procedure | Screening | Stage 1 | Stage 2 | ||||
| Baseline | Week 4 | Week 8 | Baseline | Week 4 | Week 8 | ||
| Informed consent | Х | ||||||
| Eligibility for enrolment | Х | ||||||
| Demographics | Х | Х | |||||
| Physical examination | Х | Х | Х | Х | Х | Х | |
| Clinical information | |||||||
| Diagnosis | Х | Х | |||||
| Course of treatment | Х | Х | |||||
| Family history | Х | Х | |||||
| Scales assessment | |||||||
| MARDS | Х | Х | Х | Х | Х | Х | Х |
| HAMD-17 | Х | Х | Х | Х | Х | Х | Х |
| HAMA | Х | Х | Х | Х | Х | Х | |
| MOCA | Х | Х | Х | Х | Х | Х | |
| CGI-S | Х | Х | Х | Х | Х | Х | |
| CGI-I | Х | Х | Х | Х | |||
| QIDS-SR16 | Х | Х | Х | Х | Х | Х | |
| PSQI | Х | Х | Х | Х | Х | Х | |
| Blood samples | Х | Х | Х | Х | Х | Х | |
| Stool samples | Х | Х | Х | Х | Х | Х | |
| Medication record | Х | Х | Х | Х | Х | Х | |
| Adverse events | Х | Х | Х | Х | Х | Х | |
iMORE consists of two stages: the observation phase and the validation phase. Only baseline visit is scheduled for healthy controls.
CGI-I, Clinical Global Impressions Scale-Global Improvement; CGI-S, Clinical Global Impressions Scale-Severity of Illness; HAMA, Hamilton Anxiety Rating Scale; HAMD-17 item, Hamilton Depression Rating Scale; iMORE, Integrated Module of Multidimensional Omics for Peripheral Biomarkers; MADRS, Montgomery-Asberg Depression Rating Scale; MOCA, Montreal Cognitive Assessment Scale; PSQI, The Pittsburgh Sleep Quality Index; QIDS-SR 16 item, Quick Inventory of Depressive Symptomatology-Self Report.