Table 1

Inclusion and exclusion criteria

Inclusion criteriaMedical

  • ≥18 years.

  • Coronary artery disease (acute coronary syndrome/stable angina documented in medical records).

  • Current statin therapy.

  • hsCRP >2 mg/L.

Dental

  • ≥15 teeth.

  • Not treated for gum disease (subgingival scaling and root planning) in the last 6 months.

  • Moderate to severe periodontitis.34

Exclusion criteriaMedical

  • Current or recent antibiotic therapy in the (last 3 months).

  • Pregnant, lactating of planning pregnancy.

  • Severe renal impairment: Glomerular filtration rate (GFR) <30.

  • Severe hepatic impairment: History of CKD and or alanine aminotransferase >3 upper limit of normal.

  • Blood dyscrasias.

  • Taking medications that interact with colchicine.

  • hsCRP, high sensitivity C reactive protein.