Linear regressions for 10-year risk (continuous %) as per the Framingham Risk Score, Pooled Cohort Equations and QRISK3 algorithm
Unadjusted | Adjusted | |||
β-coefficient (95% CI) | P value | Adjusted β-coefficient (95% CI) | P value | |
Framingham Risk Score | ||||
PA status | 1.39 (–0.27 to 3.05) | 0.10 | −0.32 (–2.99 to 2.34) | 0.81 |
Absolute deviation of systolic BP from median systolic BP | 0.07 (–0.003 to 0.14) | 0.06 | 0.01 (–0.09 to 0.11) | 0.82 |
Interaction term between PA status and absolute deviation of systolic BP from median systolic BP | – | – | 0.12 (–0.02 to 0.27) | 0.09 |
Pooled Cohort Equations | ||||
PA status | 2.89 (–0.72 to 6.51) | 0.12 | 3.27 (–2.62 to 9.16) | 0.27 |
Absolute deviation of systolic BP from median systolic BP | −0.002 (–0.18 to 0.17) | 0.98 | 0.02 (–0.22 to 0.25) | 0.88 |
Interaction term between PA status and absolute deviation of systolic BP from median systolic BP | – | – | −0.03 (–0.38 to 0.32) | 0.87 |
QRISK3 | ||||
PA status | 0.48 (–2.44 to 3.39) | 0.75 | −2.57 (–7.24 to 2.09) | 0.28 |
Absolute deviation of systolic BP from median systolic BP | 0.24 (0.11 to 0.36) | <0.001 | 0.11 (–0.10 to 0.31) | 0.31 |
Interaction term between PA status and absolute deviation of systolic BP from median systolic BP | – | – | 0.21 (–0.05 to 0.47) | 0.12 |
Each of the models was run independently. The Framingham Risk Score model included 242 participants; the Pooled Cohort Equations model included 141 participants; and the QRISK3 model included 217 participants.
BP, blood pressure; PA, primary aldosteronism .