Inclusion and exclusion criteria
| Inclusion criteria | |
| (1) | Age ≧20 and ≦79 years |
| (2) | Treatment with statin for more than 4 weeks |
| (3) | Fasting TG levels ≧177 mg/dL (2 mmol/L) |
| (4) | Patients who showed written consent form |
| Exclusion criteria | |
| (1) | Fasting TG levels ≧500 mg/dL (5.7 mmol/L) |
| (2) | Diabetic patients with glycated haemoglobin A1c levels ≧9% and who need insulin treatment |
| (3) | Type 1 diabetes |
| (4) | Serum creatinine levels ≧1.5 mg/dL or higher |
| (5) | Patients who used fibrates and nicotinic acids within 4 weeks |
| (6) | Patients who used PUFAs including supplements within 24 weeks |
| (7) | Symptomatic cardiovascular and cerebrovascular disorders |
| (8) | Severe infections |
| (9) | Acute hepatitis or liver cirrhosis |
| (10) | Cancer |
| (11) | Patients before or after surgery |
| (12) | Women with pregnancy or during breastfeeding |
| (13) | Patients who need lipid management with PCSK9 inhibitors or MTP inhibitors |
| (14) | Patients who have contraindications for pemafibrate and Omega-3 |
MTP, microsomal triglyceride transfer protein; Omega-3, omega-3 fatty acid ethyl esters; PCSK9, proprotein convertase subtilisin/kexin type 9; PUFAs, polyunsaturated fatty acids; TG, triglyceride.