Table 1

Overview of the measurements

Time pointBaseline (T0)6 weeks (T1)6 months (T2)1 year (T3)2 years (T4)
MRI of kneeXX
  • Features of knee OA (MOAKS)

Questionnaire + physical examinationXX
  • Clinical knee and hand OA (ACR)

MRI of kneeXX
  • Knee OA (MRI definition)

Radiograph of handsXX
  • Features of hand OA (OARSI atlas)

  • Background characteristics

  • Pain locations (manikin)


  • Reproductive status

  • Medical history/current medical problems

  • Medication use

  • Family history

  • Cardiovascular symptoms

Physical examinationXX
  • Body height and weight

  • Knee: range of motion

  • Inspection and palpation of tendons

  • Quadriceps strength

  • PPT of knees and forearm

Blood measurementsXXXXX
  • Glucose, cholesterol and hormones*

  • Cardiometabolic and inflammatory related proteins

  • DNA-methylation

  • Immunological aspects of cells

Photograph of handsXXXXX
  • Hand structures

Dual energy X-ray absorptiometry scanXX
  • BMD total body, hip and lumbar spine

  • TBS lumbar spine

  • Fat/muscle mass distribution

  • Vertebral fractures

Ultrasound Tissue Characterisation of Achilles tendonXX
  • Tendon structure, AP diameter, cross-sectional area and volume

  • *Glucose, low-density lipoprotein, high-density lipoprotein, total cholesterol, triglyceride, estradiol, testosterone, androstenedione and 17-hydroxyprogesterone.

  • ACR, American College of Rheumatology; AP, anterior to posterior; AUSCAN, Australian Canadian Osteoarthritis Hand Index; BMD, bone mineral density; KOOS, Knee injury and Osteoarthritis Outcome Score; MOAKS, MRI Osteoarthritis Knee Score; MRS, Menopause Rating Scale; OA, osteoarthritis; OARSI, Osteoarthritis Research Society International; PPT, pain pressure threshold; SQUASH, Short Questionnaire to Assess Health-enhancing physical activity; TBS, Trabecular Bone Score.