Table 1

Overview of the measurements

Time point	Baseline (T0)	6 weeks (T1)	6 months (T2)	1 year (T3)	2 years (T4)
Measurement
PRIMARY OUTCOME
MRI of knee	X				X
Features of knee OA (MOAKS)	X				X
SECONDARY OUTCOMES
Questionnaire + physical examination	X				X
Clinical knee and hand OA (ACR)	X				X
MRI of knee	X				X
Knee OA (MRI definition)	X				X
Radiograph of hands	X				X
Features of hand OA (OARSI atlas)	X				X
OTHER VARIABLES
Questionnaires	X	X	X	X	X
Background characteristics
Pain locations (manikin)
KOOS/AUSCAN/SQUASH/MRS
Reproductive status
Medical history/current medical problems
Medication use
Family history
Cardiovascular symptoms
Physical examination	X				X
Body height and weight
Knee: range of motion
Inspection and palpation of tendons
Quadriceps strength
PPT of knees and forearm
Blood measurements	X	X	X	X	X
Glucose, cholesterol and hormones*
Cardiometabolic and inflammatory related proteins
DNA-methylation
Immunological aspects of cells
Photograph of hands	X	X	X	X	X
Hand structures	X	X	X	X	X
Dual energy X-ray absorptiometry scan	X				X
BMD total body, hip and lumbar spine
TBS lumbar spine
Fat/muscle mass distribution
Vertebral fractures
Ultrasound Tissue Characterisation of Achilles tendon	X				X
Tendon structure, AP diameter, cross-sectional area and volume	X				X

*Glucose, low-density lipoprotein, high-density lipoprotein, total cholesterol, triglyceride, estradiol, testosterone, androstenedione and 17-hydroxyprogesterone.
ACR, American College of Rheumatology; AP, anterior to posterior; AUSCAN, Australian Canadian Osteoarthritis Hand Index; BMD, bone mineral density; KOOS, Knee injury and Osteoarthritis Outcome Score; MOAKS, MRI Osteoarthritis Knee Score; MRS, Menopause Rating Scale; OA, osteoarthritis; OARSI, Osteoarthritis Research Society International; PPT, pain pressure threshold; SQUASH, Short Questionnaire to Assess Health-enhancing physical activity; TBS, Trabecular Bone Score.