Table 1

Reirradiation options for previously irradiated prostate cancer schedule of events

Item\Time pointBaselineDuring RT1-month FU3-month FU6-month FU12-month FU18-month FU24-month FU
Informed consentx
Confirmation of eligibilityx
Randomisation to BT or SBRTx
Pretreatment prostate biopsy sample requested and storedx
Collection of clinical history and outcome dataxx
Radiotherapy (BT or SBRT) detailsxx
PSA testxxxxxx
Functional prostate mpMRIxxx
PROM assessment (EPIC-26, EORTC QLQ-C30 and IPSS)xxxxxx
Research blood test/urinexxxx
Clinician reported adverse eventsxxxxxxx
  • BT, brachytherapy; EBRT, external beam radiotherapy; EPIC-26, Expanded Prostate Cancer Index Composite-26; FU, follow-up; IPSS, International Prostate Symptom Score; mpMRI, multiparametric MRI; PROM, patient-recorded outcome measure; PSA, prostate specific antigen; EORTC QLQ, European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire; RT, radiotherapy.