Table 1

Reirradiation options for previously irradiated prostate cancer schedule of events

Item\Time point	Baseline	During RT	1-month FU	3-month FU	6-month FU	12-month FU	18-month FU	24-month FU
Informed consent	x
Registration	x
Testosterone	x
Confirmation of eligibility	x
Randomisation to BT or SBRT	x
Pretreatment prostate biopsy sample requested and stored	x
Collection of clinical history and outcome data	x							x
Radiotherapy (BT or SBRT) details	x	x
PSA test	x			x	x	x	x	x
Functional prostate mpMRI	x		x			x
PROM assessment (EPIC-26, EORTC QLQ-C30 and IPSS)	x		x	x	x	x		x
Research blood test/urine	x		x	x	x
Clinician reported adverse events		x	x	x	x	x	x	x

BT, brachytherapy; EBRT, external beam radiotherapy; EPIC-26, Expanded Prostate Cancer Index Composite-26; FU, follow-up; IPSS, International Prostate Symptom Score; mpMRI, multiparametric MRI; PROM, patient-recorded outcome measure; PSA, prostate specific antigen; EORTC QLQ, European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire; RT, radiotherapy.