Table 3

Timeline of the assessment of inflammatory and coagulation parameters relative to the administration of IL-6 antagonist

Day	Conventional laboratory parameters	ClotPro^® tests	Blood sample
0	Inflammatory parameters, clinical biochemistry and conventional coagulation parameters	EX, IN, FIB, TPA, RVV, ECA tests	Plasma, serum
0	Administration of IL-6 antagonist
24 hours	Inflammatory parameters, clinical biochemistry and conventional coagulation parameters	EX, IN, FIB, TPA, RVV, ECA tests
48 hours	Inflammatory parameters, clinical biochemistry and conventional coagulation parameters	EX, IN, FIB, TPA, RVV, ECA tests	Plasma, serum
5 days	Inflammatory parameters, clinical biochemistry and conventional coagulation parameters	EX, IN, FIB, TPA, RVV, ECA tests
7 days	Inflammatory parameters, clinical biochemistry and conventional coagulation parameters	EX, IN, FIB, TPA, RVV, ECA tests	Plasma, serum

ECA-test, ecarin clotting assay test; EX-test, extrinsic coagulation pathway test; FIB-test, functional fibrinogen test; IN-test, intrinsic coagulation pathway test; RVV-test, Russell’s viper venom reagent test ; TPA-test, tissue plasminogen activator test.