Table 4

Sensitivity and specificity, positive and negative predictive values (PPV, NPV) with 95% CI of HPV self-sampling test, Pap smear, VIA test individually and in combination to detect CIN2+; N=512

Screening testSensitivity (95% CI)Specificity (95% CI)PPV (95% CI)NPV (95% CI)
HPV test62.5 (59.5 to 74.3)59.3 (54.6 to 63.9)18 (13.2 to 23.7)91.7 (87.9 to 94.6)
Pap smear82.8 (71.3 to 91.1)82.1 (78.2 to 85.5)39.8 (31.5 to 48.7)97.1 (94.8 to 98.5)
VIA48.4 (35.8 to 61.3)56.8 (53.3 to 89.8)34.4 (24.7 to 45.2)92.1 (89.1 to 94.5)
HPV+Pap smear90.6 (80.7 to 96.5)70.6 (65.8 to 75.3)20.8 (16.2 to 26.0)97.4 (94.5 to 99.0)
HPV test+VIA65.6 (52.7 to 77.1)75.5 (70.7 to 80.2)17.4 (12.9 to 22.8)91.9 (87.9 to 94.8)
  • HPV, human papillomavirus; VIA, visual inspection of the cervix with acetic acid.