Table 3

Maternal outcomes in pregnant women with and without rheumatoid arthritis

No of events (%)Crude OR (95% CI)Adjusted OR (95% CI)†
With RA (n=922)Without RA (n=2 099 221)
Death
 Death ≤30 days post partum00.00281(0.01)N/AN/A
 Death ≤1 year post partum-‡682(0.03)3.35(0.47 to 23.82)2.35(0.32 to 17.17)
Cardiovascular events
 Acute myocardial infarction00.00106(0.01)N/AN/A
 Shock00.001284(0.06)N/AN/A
 Arrhythmias requiring cardioversion-‡708(0.03)3.38(0.48 to 23.88)2.61(0.37 to 18.56)
 Pregnancy-related hypertension34(3.69)54 806(2.61)1.45(1.02 to 2.07)*1.14(0.79 to 1.63)
 Pre-eclampsia26(2.82)36 792(1.75)1.66(1.10 to 2.50)*1.30(0.85 to 1.97)
 Eclampsia00.001533(0.07)N/AN/A
 Puerperal cerebrovascular diseases-‡1799(0.09)1.20(0.17 to 8.43)0.80(0.11 to 5.76)
 Thromboembolism00.00233(0.01)N/AN/A
Events and procedures during delivery
 Amniotic fluid embolism00.00227(0.01)N/AN/A
 Antepartum haemorrhage106(11.50)188 113(8.96)1.33(1.08 to 1.64)*1.24(1.00 to 1.52)*
 Severe postpartum haemorrhage35(3.80)58 395(2.78)1.42(1.01 to 1.99)*1.37(0.98 to 1.93)
 Premature rupture of membranes00.00840.00N/AN/A
 Chorioamnionitis6(0.65)8075(0.38)1.68(0.76 to 3.74)1.54(0.69 to 3.43)
 Caesarean delivery398(43.17)705 109(33.59)1.57(1.37 to 1.80)*1.32(1.15 to 1.51)*
Events and procedures during surgery
 Severe anaesthesia complications00.00230(0.01)N/AN/A
 Thorax, abdomen and pelvis injuries-‡896(0.04)2.64(0.37 to 18.68)2.46(0.35 to 17.47)
 Intracranial injuries4(0.43)4937(0.24)1.88(0.71 to 5.00)1.73(0.64 to 4.69)
 Blood transfusion10(1.08)13 342(0.64)1.70(0.90 to 3.19)1.41(0.75 to 2.65)
 Hysterectomy00.001700(0.08)N/AN/A
 Operations on heart and pericardium-‡2140(0.10)1.02(0.14 to 7.17)0.78(0.11 to 5.49)
Others
 Acute renal failure00.00532(0.03)N/AN/A
 Adult respiratory distress syndrome-‡1336(0.06)1.75(0.25 to 12.39)1.28(0.18 to 9.24)
 Sepsis7(0.76)7002(0.33)2.34(1.11 to 4.91)1.95(0.92 to 4.13)
 Disseminated intravascular coagulation3(0.33)1658(0.08)4.15(1.34 to 12.88)*3.33(1.07 to 10.34)*
 Pulmonary oedema-‡330(0.02)6.44(0.91 to 45.60)4.03(0.54 to 29.83)
 Mechanical ventilation19(2.06)26 174(1.25)1.67(1.02 to 2.74)*1.35(0.82 to 2.23)
 Gestational diabetes67(7.27)13,3028(6.34)1.17(0.91 to 1.51)0.92(0.71 to 1.19)
  • *p<0.05.

  • †Adjusted for age, infant sex, Charlson Comorbidity Index, urbanisation, income, occupation, birth year and maternal nationality.

  • ‡Numbers <3 are not displayed, as per the confidentiality policies of the National Health Insurance database.

  • .N/A, not applicable; RA, rheumatoid arthritis.