Table 2

Fetal–neonatal outcomes in pregnant women with and without rheumatoid arthritis

No of events (%)Crude OR (95% CI)Adjusted OR (95% CI)*
With RA (n=922)Without RA (n=2 099 221)
Stillbirth13(1.41)16 225(0.77)1.39(0.20 to 9.84)1.55(0.89 to 2.68)
Explained stillbirth†-1639(0.08)1.89(1.07 to 3.34)‡1.16(0.16 to 8.30)
Unexplained stillbirth12(1.30)14 586(0.69)1.84(1.07 to 3.18)‡1.59(0.90 to 2.82)
Low birth weight (<2500 g)123(13.34)138 742(6.61)2.17(1.77 to 2.65)‡2.03(1.66 to 2.50)‡
Prematurity (<37 weeks)141(15.29)159 997(7.62)2.21(1.83 to 2.67)‡1.99(1.64 to 2.40)‡
Small for gestational age144(15.62)206 079(9.82)1.66(1.37 to 2.01)‡1.77(1.46 to 2.15)‡
Large for gestational age68(7.38)206 308(9.83)0.75(0.58 to 0.96)0.66(0.51 to 0.84)
Apgar score at 1 min (<7)§30(3.25)40 361(1.92)1.73(1.19 to 2.51)‡1.54(1.05 to 2.25)‡
Apgar score at 5 min (<7)§†-8275(0.39)0.28(0.04 to 1.98)0.24(0.03 to 1.71)
Fetal distress60(6.51)103 035(4.91)1.36(1.04 to 1.79)‡1.35(1.03 to 1.78)‡
Fetal abnormalities, any65(7.05)118 691(5.65)1.3(1.01 to 1.67)‡1.16(0.90 to 1.49)
  • *Adjusted for age, infant sex, Charlson comorbidity index, urbanization, income, occupation, birth year, and maternal nationality

  • †Numbers <3 is not displayed, as per the confidentiality policies of the NHI Database

  • ‡p<0.05.

  • §Apgar score of live birth

  • .NHI, National Health Insurance; RA, rheumatoid arthritis.