Table 3

Association of reproductive risk factors with breast cancer

ParameterCase
N (%)
Control
N (%)
Bivariate analysisMultivariable analysis
COR (95% CI)P valueAOR (95% CI)P value
Age at menarche (years)
>1520 (11.2)60 (28.6)1:001:001:00
12–15150 (83.8)144 (68.6)3.13 (1.79 to 5.45)0.00015.94 (1.84 to 19.15)0.003
<129 (5.0)6 (2.9)4.50 (1.42 to 14.21)0.0103.16 (1.78 to 5.56)0.001
Family history of breast
No215 (93.5)226 (98.3)1:001:001:00
Yes15 (6.5)4 (1.7)3.94 (1.29 to 12.07)0.0162.60 (0.765 to 8.81)0.126
Menopausal status
Premenopausal (ref.)122 (53.0)161 (70.0)1:001:001:00
Postmenopausal108 (47.0)69 (30.0)2.06 (1.41 to 3.03)0.0012.34 (1.50 to 3.64)0.001
History of benign breast disease
No211 (91.7)226 (98.3)1:001:001:00
Yes19 (8.3)4 (1.7)5.09 (1.70 to 15.19)0.0048.82 (1.96 to 39.60)0.005
  • Stepwise multiple logistic regression. 1:00 is OR for reference/comparison group.

  • Adjusted for: age at menarch, menoposal status, history of surgery and family history with first degree relatives.

  • AOR, adjusted OR; COR, crude OR.