Intervention | Source | Population* | Study arms | Primary outcome(s)** | Secondary outcome(s)** | Recruitment status | Date of completion |
What type of dialysis modality? | |||||||
No. 1 | Multicentre RCT170 | Patients with an eGFR <20 mL/min/1.73 m2 | Intervention:
Control:
| Within 3 months of dialysis initiation: the proportion of patients who receive any home-based dialysis modality | Pre-intervention, 6 and 12 months post-intervention/control: patient characteristics, the proportion of patients intending to perform home-based dialysis, dialysis knowledge, decisional conflict, level of social support | Not reported | Estimated study completion date: June 2017 |
No. 2 | RCT158 | Patients >75 years of age with an eGFR <25 mL/min/1.73 m2 | Intervention:
Control:
| Up to 24 months post-intervention/control: feasibility of the intervention, acceptability of the intervention | n.a. | Recruiting | Estimated completion date: May 2021 |
No. 3 | RCT159 | Patients with CKD stage 5 | Intervention:
Control:
| Post-intervention/control: control preference, knowledge, decisional self-efficacy, decisional conflict | Post-intervention/control: satisfaction with the decision, decisional regret | Completed | Actual study completion date: December 2019 |
No. 4 | RCT160 | Veterans with CKD stage 4–5 | Intervention:
control:
| Pre-intervention and 48 months post-intervention/control: home dialysis use |
| Recruiting | Estimated completion date: September 2023 |
Pursue LDKT or not? | |||||||
No. 5 | RCT171 | Black kidney transplant candidates | Intervention:
Control:
| Up to 2 years post-intervention/control: the occurrence of LDKT |
| Completed | Actual completion date: June 2020 |
No. 6 | RCT161 | Non-white race, Hispanic ethnicity or low-income kidney transplant candidates | Intervention:
Control:
| Up to 2 years post-intervention/control: the occurrence of LDKT |
| Completed | Actual completion date: May 2020 |
No. 7 | Multicentre RCT162 | Black kidney transplant candidates | Intervention:
Control:
| 1 year post-intervention/control: the occurrence of LDKT |
| Recruiting | Estimated completion date: January 2021 |
No. 8 | RCT163 | Black kidney transplant candidates | Intervention:
Control:
| Pre-intervention, 1 week and 9 months post-intervention/control: readiness to pursue LDKT |
| Completed | Actual completion date: August 2018 |
No. 9 | RCT164 | Patients with ESKD | Intervention:
Control:
| Up to 43.6 months post-intervention/control: receipt of kidney transplant |
| Completed | Actual completion date: August 2020 |
No. 10 | Non-randomised controlled study165 | Patients on HD | Intervention:
Control:
| Pre-intervention, 3 months and 1 year post-intervention/control: transplant knowledge, the number of transplant steps completed | 3 months and 1 year post-implementation/control: completion of transplant work-up, self-reported requests for living donation | Recruiting | Estimated completion date: July 2022 |
No. 11 | Multicentre RCT172 | African-American kidney transplant candidates | Intervention:
Control:
| 12 months post-intervention/control: the proportion of patients with at least one living donor inquiry |
| Recruiting | Estimated completion date: May 2022 |
Dialysis or CCM? | |||||||
No. 12 | Multicentre RCT166 |
| Intervention:
Control:
| Pre-intervention, 3, 6 and 18 months post-intervention/control: decisional conflict | Pre-intervention, 3, 6 and 18 months post-intervention/control: advance directives completion, healthcare evaluation, instability of patients’ preferences, patient/care-giver concordance on the goals of care | Active (not recruiting) | Estimated completion date: March 2022 |
No. 13 | Mixed-methods study167 | Elderly patients with ESKD | Intervention:
Control:
| Pre-intervention and post-intervention/control: treatment choice | n.a. | Not reported | Not reported |
Transplantation, dialysis or CCM? | |||||||
No. 14 | Multicentre RCT173 | Patients with AKD | Intervention:
Control:
| Pre-intervention, 12, 24 and 36 months post-intervention/control: patient empowerment, confidence with self-care, proportion of patients deciding to initiate self-care treatment, hospitalisations, proportion of patients with advance care plans for kidney failure treatment preferences broadcast in electronic health record | Pre-intervention, 12, 24 and 36 months post-intervention/control: proportion of patients with self-care biomedical care plans, proportion of patients achieving values aligned care within 6 months of kidney failure treatment initiation, values and preferences documented in electronic health record, emergency dialysis initiation, time to kidney failure, vascular access at HD initiation, patient characteristics, financial distress/well-being, kidney function, presence and control of kidney disease progression risk factors, comorbid health conditions, depression, anxiety, need for mental health support, quality of life, self-management, diet, exercise, medication adherence, duration and frequency of care, patient centredness of care, health literacy, control preference, decisional conflict, decisional self-efficacy, patient activation, barriers to complex treatment plans, kidney transitions specialist adherence to protocol, sustainability of the intervention | Completed | Actual completion date: October 2020 |
What type of transplantation? | |||||||
No. 15 | Multicentre RCT168 | Dialysis facilities | Intervention:
Control:
| Up to 2 years post-intervention/control: composite outcome of living kidney donor candidate referral and transplant recipient referral rate | Up to 2 years post-intervention/control: kidney transplantation rate, rate of pre-emptive kidney transplantation, rate of kidney transplant wait listing, average healthcare costs | Active (not recruiting) | Estimated completion date: March 2021 |
No. 16 | Multicentre RCT169 | Patients with CKD stage 3–5 | Intervention:
Control:
| Pre-intervention and 6 months post-intervention/control: DDKT and LDKT knowledge |
| Active (not recruiting) | Estimated completion date: August 2020 |
*Study population formulated as reported in the identified records.
†Outcomes formulated as reported in the identified records.
AKD, advanced kidney disease; CKD, chronic kidney disease; CKD-EDU, chronic kidney disease enhanced dialysis education; COACH, communicating about choices in transplantation; DDKT, deceased donor kidney transplantation; eGFR, estimated glomerular filtration rate; ESKD, end stage kidney disease; ET, explore transplant; HD, haemodialysis; KRT, kidney replacement therapy; LDKT, living donor kidney transplantation; n.a., not applicable; PD, peritoneal dialysis; RCT, randomised controlled trial; SDM, shared decision-making; WISHED, web-based interactive health communication application for successful home dialysis.