Table 2

Summary of eligibility criteria for the CONTACTS study

Cohort	Inclusion	Exclusion
Both	≥16 years old Requires admission to QEHB Injury sustained within 24 hours of presentation	Police custody Prisoner Evidence of intracranial injury on CT (if performed as part of standard clinical care) Significant communication barriers Not fluent in the English language Medical history of neurological or cognitive impairment
Concussed	Diagnosis of maxillofacial injury Clinical features consistent with a diagnosis of concussion History of direct blow to the head, face, neck or elsewhere on the body with an ‘impulsive’ force transmitted to the head. History of rapid onset of short-lived impairment of neurological function that resolves spontaneously. No evidence of structural abnormality to the brain seen on standard neuroimaging. LOC ≤30 min. GCS score ≥13 on presentation. PTA ≤24 hours.	LOC >30 min GCS <13 on presentation PTA lasting >24 hours (assess at 24 hours) Mechanism of injury due to organised sports activity
Control	Diagnosis of isolated limb injury	History of TBI Clinical features consistent with a diagnosis of concussion according to CISG criteria and ACRM definition Insufficiency, open, femoral or tibia–fibula fracture

ACRM, American Congress of Rehabilitation Medicine; CISG, Concussion in Sport Group; CONTACTS, Concussion in Non-Athletes: Assessment of Cognition and Symptomatology; GCS, Glasgow Coma Scale; LOC, loss of consciousness; PTA, post-traumatic amnesia; QEHB, Queen Elizabeth Hospital Birmingham; TBI, traumatic brain injury.