Confounder/mediator | Total effect | Direct effect | Indirect effect | Proportions of mediation effects | ||||||
Estimates | 95% CI | P value | Estimates | 95% CI | P value | Estimates | 95% CI | P value | % (95% CI) | |
Any CM | 0.312 | 0.151 to 0484 | <0.001 | |||||||
BMI | 0.301 | 0.140 to 0.463 | <0.001 | 0.011 | −0.004 to 0.026 | 0.164 | 3.5 (−1.6 to 11) | |||
HbA1c | 0.314 | 0.151 to 0.473 | <0.001 | −0.002 | −0.015 to 0.011 | 0.750 | −0.6 (−5.5 to 1.6) | |||
HIV-positive | 0.310 | 0.148 to 0.471 | <0.001 | 0.002 | −0.014 to 0.018 | 0.823 | 0.9 (2.9 to 6.3) | |||
Current smoking | 0.308 | 0.144 to 0.468 | <0.001 | 0.003 | −0.029 to 0.034 | 0.872 | 0.5 (−3.8 to 6.8) | |||
Current alcohol | 0.282 | 0.119 to 0.444 | <0.001 | 0.029 | 0.001 to 0.058 | 0.049 | 5.6 (1.2 to 16.7) | |||
Depressive symptom score | 0.282 | 0.122 to 0.443 | <0.001 | 0.029 | 0.004 to 0.053 | 0.022 | 12.5 (3.6 to 29.5) | |||
ASR score | 0.287 | 0.124 to 0.449 | <0.001 | 0.024 | 0.008 to 0.055 | 0.045 | 10.5 (1.5 to 29) | |||
Other traumatic exposures score | 0.232 | 0.067 to 0.397 | 0.006 | 0.081 | 0.045 to 0.118 | <0.001 | 27.2 (16.9 to 68.6) | |||
Multiple CM types | 0.243 | 0.138 to 0.349 | <0.001 | |||||||
BMI | 0.236 | 0.130 to 0.342 | <0.001 | 0.008 | −0.003 to 0.018 | 0.157 | 2.1 (1.5 to 8.4) | |||
HbA1c | 0.244 | 0.138 to 0.349 | <0.001 | −0.001 | −0.009 to 0.007 | 0.777 | 0.1 (−3.3 to 2.2) | |||
HIV-positive | 0.238 | 0.132 to 0.344 | <0.001 | 0.005 | −0.006 to 0.017 | 0.374 | 1.8 (0.9 to 6.8) | |||
Current smoking | 0.240 | 0.132 to 0.348 | <0.001 | 0.001 | −0.026 to 0.027 | 0.959 | 0.1 (−4.9 to 5.9) | |||
Current alcohol | 0.223 | 0.116 to 0.330 | <0.001 | 0.020 | 0.001 to 0.040 | 0.046 | 5.6 (0.8 to 12.4) | |||
Depressive symptom score | 0.220 | 0.113 to 0.326 | <0.001 | 0.022 | 0.001 to 0.043 | 0.037 | 11 (3 to 26) | |||
ASR score | 0.226 | 0.119 to 0.333 | <0.001 | 0.016 | 0.001 to 0.039 | 0.051 | 9.2 (1.0 to 25.3) | |||
Other traumatic exposures score | 0.178 | 0.069 to 0.287 | 0.001 | 0.066 | 0.057 to 0.095 | <0.001 | 30.9 (15 to 60) | |||
Cumulative CM score | 0.094 | 0.055 to 0.132 | <0.001 | |||||||
BMI | 0.092 | 0.053 to 0.130 | <0.001 | 0.002 | −0.002 to 0.005 | 0.363 | 0.3 (−3.3 to 6.5) | |||
HbA1c | 0.094 | 0.056 to 0.133 | <0.001 | −0.001 | −0.004 to 0.001 | 0.347 | −0.4 (−4.2 to 1.2) | |||
HIV-positive | 0.092 | 0.054 to 0.131 | <0.001 | 0.001 | −0.004 to 0.005 | 0.704 | 1.1 (−1.4 to 5.5) | |||
Current smoking | 0.092 | 0.053 to 0.132 | <0.001 | 0.000 | −0.010 to 0.011 | 0.994 | −0.4 (−5.1 to 6) | |||
Current alcohol | 0.086 | 0.048 to 0.126 | <0.001 | 0.007 | 0.001 to 0.014 | 0.049 | 4.5 (0.6 to 12) | |||
Depressive symptom score | 0.084 | 0.045 to 0.123 | <0.001 | 0.008 | 0.001 to 0.017 | 0.047 | 11.1 (2.1 to 24.8) | |||
ASR score | 0.087 | 0.047 to 0.126 | <0.001 | 0.006 | 0.000 to 0.016 | 0.193 | 8.6 (0.8 to 22.4) | |||
Other traumatic exposures score | 0.067 | 0.027 to 0.107 | 0.001 | 0.027 | 0.015 to 0.038 | <0.001 | 31.5 (16.5 to 65.4) |
Data are standardised beta coefficient; current smoking: currently smoke any tobacco products such as cigarettes, cigars or pipes; current alcohol consumption: consumed at least one drink in an occasion within a month, respectively (one drink is equivalent to one can/bottle of beer, cider, cooler/glass of wine/tot of spirit); depressive symptom (scores): depressive symptoms during the past week using Centre for Epidemiologic Studies Depression Scale (CES-D score); ASR (scores): acute stress reactions measured using Davidson Trauma Scale, a validated self-rating scale. Cumulative abuse (score): ranged from 0 (no abused in any type) to 8 (often/severely abused in all four types).
BMI, body mass index; CM, childhood maltreatment.