Table 3

Associations of MetSyn and its components with the incidence of cancer in different models

Controls (918)Cases (306)Model 1Model 2IPTW
OR (95% CI)P valueOR (95% CI)P valueOR (95% CI)P value
No MetSyn component138361 (ref)1 (ref)1 (ref)
Any MetSyn components780270
No of components of MetSyn
 1303 (38.9)93 (34.5)1.21 (0.77 to 1.89)0.4081.21 (0.77 to 1.88)0.3871.03 (0.85 to 1.24)0.798
 2253 (32.4)74 (27.4)1.20 (0.75 to 1.91)0.4481.20 (0.75 to 1.91)0.4521.01 (0.82 to 1.24)0.931
 ≥3224 (28.7)103 (38.1)1.96 (1.23 to 3.11)0.0051.95 (1.23 to 3.10)0.0051.65 (1.06 to 2.58)0.026
 P for trend0.0060.0030.302
Unique MetSyn component
 Elevated waist circumference84 (27.7)28 (30.1)2.09 (0.75 to 5.81)0.1572.06 (0.74 to 5.77)0.1691.10 (0.80 to 1.51)0.577
 Elevated triglycerides34 (11.2)11 (11.8)1.43 (0.54 to 3.74)0.4721.45 (0.55 to 3.83)0.4511.15 (0.84 to 1.57)0.390
 Reduced HDL cholesterol00
 Elevated blood pressure33 (10.9)12 (12.9)1.07 (0.43 to 2.68)0.8811.05 (0.42 to 2.63)0.9241.30 (0.95 to 1.79)0.106
 Elevated fasting plasma glucose152 (50.2)42 (45.2)1.05 (0.57 to 1.94)0.8771.08 (0.58 to 2.01)0.8000.90 (0.73 to 1.11)0.333
Any MetSyn components
 Elevated waist circumference399 (51.2)142 (52.6)1.54 (0.95 to 2.51)0.0801.54 (0.95 to 2.50)0.0831.02 (0.81 to 1.28)0.854
 Elevated triglycerides319 (40.9)132 (48.9)1.66 (1.07 to 2.56)0.0221.65 (1.07 to 2.56)0.0231.01 (0.82 to 1.25)0.924
 Reduced HDL cholesterol91 (11.7)55 (20.4)2.40 (1.44 to 4.01)<0.0012.40 (1.44 to 4.01)<0.0011.56 (1.02 to 2.40)0.041
 Elevated blood pressure217 (27.8)91 (33.7)1.69 (1.07 to 2.67)0.0241.69 (1.07 to 2.67)0.0251.28 (1.03 to 1.60)0.029
 Elevated fasting plasma glucose538 (69.0)190 (70.4)1.42 (0.93 to 2.15)0.1011.41 (0.93 to 2.14)0.1050.96 (0.80 to 1.15)0.636
No of components of MetSyn*
 0110311 (ref)1 (ref)1 (ref)
 1267761.04 (0.64 to 1.69)0.8761.04 (0.64 to 1.69)0.8690.91 (0.74 to 1.12)0.358
 2210641.15 (0.69 to 1.89)0.5971.15 (0.69 to 1.90)0.5930.95 (0.76 to 1.20)0.683
 ≥3202921.78 (1.09 to 2.93)0.0221.79 (1.09 to 2.94)0.0221.60 (1.00 to 2.56)0.050
  • Model 1: adjusted for education level, smoking status, drinking status and depression scores.

  • Model 2: model 1 with marital status.

  • IPTW: adjusted for age, sex, education level, smoking status, drinking status and depression scores.

  • *The first visit at 2013 was excluded.

  • HDL, high-density lipoprotein; IPTW, inverse probability of treatment weighting; MetSyn, metabolic syndrome.