Table 2

Risk factors for mortality in the entire cohort

Variable	Reference	Univariate analysis		Multivariate analysis
Variable	Reference	HR (95% CI)	P value	HR (95% CI)	P value
Birth weight*
Extremely low birth weight (<1000 g)	Normal birth weight (>2500 g)	2.138 (1.02 to 4.50)	0.0453	1.10 (0.49 to 2.46)	0.826
Low/very low birth weight (1000–<2500 g)		0.408 (0.21 to 0.81)	0.0104	0.24 (0.11 to 0.53)	<0.001
Sepsis
Yes	No	1.95 (1.00 to 3.82)	0.05	1.73 (0.83 to 3.63)	0.140
Blood culture sent
Yes	No	0.69 (0.21 to 2.30)	0.55
Bug–drug mismatch
Yes	No	0.857 (0.05 to 13.70)	0.9132
HIE
Yes	No	2.20 (1.22 to 3.97)	0.0086	1.59 (0.81 to 3.11)	0.177
Maternal illness at time of delivery
Yes	No	0.506 (0.12 to 2.09)	0.3468
Congenital deformity
Yes	No	1.824 (0.65 to 5.10)	0.2509
Sex
Male	Female	1.106 (0.62 to 1.97)	0.7342
HIV exposure
Yes	No	0.524 (0.22 to 1.24)	0.141
Born at home
Yes	No	3.025 (1.18 to 7.73)	0.0207	4.82 (1.76 to 13.19)	0.002
Mode of delivery
C-section	Vaginal	0.726 (0.37 to 1.44)	0.3598
Critical illness
Yes	No	3.842 (2.13 to 6.93)	<0.0001	3.07 (1.56 to 6.03)	0.001
Sepsis pathway followed
Yes	No	0.785 (0.26 to 2.35)	0.6649
Drug shortages
Yes	No	1.43 (0.51 to 4.00)	0.4958
Appropriate antibiotics prescribed
No	Yes	1.679 (0.89 to 3.19)	0.1128
Blood culture sent
Yes	No	0.784 (0.42 to 1.47)	0.4467
Clinical pathway availability
Yes	No	2.176 (0.77 to 6.12)	0.1408