Outcome | Clinical condition | Events | Proportion of patients with events | P-years (1000 years) | Incidence (per 1000 p-years) | Unadjusted IRR | Adjusted IRR |
Any AAT | No MHC | 43 901 | 22.9% | 606.88 | 72.3 (71.7–73.0) | (Reference) | (Reference) |
Any MHC | 8032 | 16.9% | 148.40 | 54.1 (53.0–55.3) | 0.748 (0.731–0.766) | 0.811 (0.791–0.831) | |
Depression | 1893 | 17.3% | 29.72 | 63.7 (60.9–66.6) | 0.880 (0.841–0.922) | 0.805 (0.768–0.844) | |
Bipolar disorder | 212 | 18.8% | 3.35 | 63.3 (55.3–72.4) | 0.875 (0.764–1.001) | 0.730 (0.637–0.835) | |
Anxiety disorder | 804 | 18.4% | 11.53 | 69.8 (65.1–74.8) | 0.964 (0.899–1.034) | 0.706 (0.658–0.757) | |
Schizophrenia | 137 | 8.8% | 4.20 | 32.7 (27.6–38.6) | 0.451 (0.382–0.534) | 0.408 (0.345–0.482) | |
AADs | No MHC | 17 927 | 9.4% | 725.31 | 24.7 (24.4–25.1) | (Reference) | (Reference) |
Any MHC | 3548 | 7.5% | 168.47 | 22.3 (21.6–23.0) | 0.852 (0.822–0.883) | 0.889 (0.857–0.923) | |
Depression | 801 | 7.3% | 33.50 | 23.9 (22.3–25.6) | 0.967 (0.901–1.038) | 0.911 (0.848–0.979) | |
Bipolar disorder | 83 | 7.4% | 3.84 | 21.6 (17.5–26.8) | 0.876 (0.706–1.086) | 0.780 (0.628–0.969) | |
Anxiety disorder | 347 | 7.9% | 13.04 | 26.6 (23.9–29.6) | 1.076 (0.968–1.197) | 0.832 (0.747–0.926) | |
Schizophrenia | 50 | 3.2% | 4.53 | 11.0 (8.5–14.6) | 0.447 (0.339–0.590) | 0.423 (0.320–0.558) | |
Cardioversion | No MHC | 33 446 | 17.4% | 660.17 | 50.7 (50.1–51.2) | (Reference) | (Reference) |
Any MHC | 5867 | 12.3% | 159.28 | 36.8 (35.9–37.8) | 0.727 (0.707–0.748) | 0.794 (0.772–0.817) | |
Depression | 1408 | 12.9% | 31.65 | 44.5 (42.2–46.9) | 0.878 (0.833–0.926) | 0.797 (0.755–0.842) | |
Bipolar disorder | 161 | 14.3% | 3.55 | 45.4 (38.9–53.0) | 0.896 (0.768–1.046) | 0.744 (0.637–0.869) | |
Anxiety disorder | 567 | 12.9% | 12.43 | 45.6 (42.0–49.5) | 0.900 (0.829–0.978) | 0.663 (0.610–0.721) | |
Schizophrenia | 96 | 6.2% | 4.33 | 22.2 (18.1–27.1) | 0.438 (0.358–0.535) | 0.391 (0.320–0.477) | |
Catheter ablation | No MHC | 4309 | 2.2% | 799.94 | 5.4 (5.2–5.5) | (Reference) | (Reference) |
Any MHC | 801 | 1.7% | 183.44 | 4.4 (4.1–4.7) | 0.811 (0.752–0.874) | 0.837 (0.775–0.904) | |
Depression | 217 | 2.0% | 36.15 | 6.0 (5.3–6.9) | 1.114 (0.972–1.277) | 0.904 (0.787–1.040) | |
Bipolar disorder | 20 | 1.8% | 4.08 | 4.9 (3.2–7.6) | 0.911 (0.587–1.413) | 0.660 (0.425–1.027) | |
Anxiety disorder | 80 | 1.8% | 14.13 | 5.7 (4.5–7.0) | 1.051 (0.842–1.311) | 0.564 (0.451–0.705) | |
Schizophrenia | 6 | 0.4% | 4.67 | 1.3 (0.6–2.9) | 0.238 (0.107–0.531) | 0.215 (0.097–0.480) |
95% CIs in parenthesis. IRRs are estimated by Poisson regression and adjusted for age, sex, calendar year of atrial fibrillation diagnosis, dementia, alcohol use disorder, vascular disease and heart failure.
AAD, antiarrhythmic drug; IRR, incidence rate ratio.