Table 5

Strength of responders’ opinions as to likelihood of missing studies in RD <1 cm versus RD =0 cm and number of studies elicited

Strength of opinion of likelihood of missing studiesnEstimated missing studiesEffect estimates*
Mean (SD)Median (IQR)RangeLogHR (SElogHR)HR (95% CI)
‘Not likely’10000 (0.25)†1.0 (0.61 to 1.63)†
‘Somewhat likely’55.8 (2.4)5 (5–5)4–10−0.098 (0.074)0.91 (0.78 to 1.05)
‘Quite likely’817.8 (13.9)12.5 (10–20)7–50−0.144 (0.054)0.87 (0.78 to 0.96)
‘Very/extremely likely’437.540(25–50)20–50−0.078 (0.035)0.92 (0.86 to 0.99)
All responders1817.8 (16.5)10 (5–20)0–50−0.103 (0.066)0.90 (0.79 to 1.03)
  • *Calculated using a simple weighted average of each responder.

  • †No studies were estimated from responder so for purposes of analysis and calculation of pooled estimate, one small and imprecise study was used.

  • RD, residual disease.