Table 2

COVID-19 diagnosis in people prescribed methotrexate and/or folic acid in the UKBB, compared with people not prescribed methotrexate or folic acid

UnadjustedModel 1Model 2
OR (95% CI)P valueOR (95% CI)P valueOR (95% CI)P value
Neither folic acid nor methotrexate, N=363 8211.01.01.0
Folic acid only, N=12 4331.58 (1.49 to 1.68)<0.0011.60 (1.50 to 1.70)<0.0011.51 (1.42 to 1.61)<0.001
Methotrexate only, N=1740.94 (0.51 to 1.72)0.830.89 (0.48 to 1.65)0.720.86 (0.47 to 1.6)0.64
Methotrexate and folic acid, N=39521.09 (0.96 to 1.23)0.181.15 (1.02 to 1.30)0.0211.09 (0.96 to 1.23)0.18
  • Model 1 adjusted for age group, sex, ethnicity, Townsend deprivation index, body mass index, smoking status.

  • Model 2 is model 1 plus adjustment by the presence of rheumatoid arthritis, sickle cell disease, use of statins, anticonvulsants and iron supplementation.