HRs of venous thromboembolism between control subjects and early or late Helicobacter pylori eradication
| Control (N=26 944) | Early eradication (N=3062) | IRR (95% CI) | Adjusted HR | Late eradication (N=3674) | IRR (95% CI) | Adjusted HR† | ||||
| Event | Rate* | Event | Rate* | (95% CI) | Event | Rate* | (95% CI) | |||
| All | 414 | 2.91 | 54 | 3.04 | 1.04 (0.93 to 1.18) | 1.12 (0.84 to 1.49) | 272 | 15.2 | 5.22 (4.90 to 5.57)‡ | 3.91 (3.33 to 4.59)‡ |
| Gender | ||||||||||
| Female | 220 | 3.46 | 23 | 3.14 | 0.91 (0.75 to 1.10) | 0.96 (0.62 to 1.48) | 171 | 20.5 | 5.92 (5.40 to 6.48)‡ | 4.39 (3.54 to 5.43)‡ |
| Male | 194 | 2.47 | 31 | 2.97 | 1.20 (1.04 to 1.39)‡ | 1.29 (0.88 to 1.89) | 101 | 10.6 | 4.29 (3.91 to 4.71)‡ | 3.13 (2.43 to 4.03)‡ |
| Age | ||||||||||
| ≤49 | 83 | 1.27 | 28 | 2.82 | 2.23 (1.96 to 2.53)‡ | 2.07 (1.34 to 3.18)‡ | 12 | 1.83 | 1.45 (1.21 to 1.73)‡ | 1.29 (0.69 to 2.41) |
| 50–65 | 138 | 2.83 | 22 | 4.10 | 1.45 (1.19 to 1.76)‡ | 1.43 (0.91 to 2.24) | 145 | 22.1 | 7.78 (7.04 to 8.61)‡ | 5.44 (4.21 to 7.03)‡ |
| ≥65 | 193 | 6.92 | 4 | 1.62 | 0.23 (0.14 to 0.40)‡ | 0.21 (0.08 to 0.56)‡ | 115 | 24.2 | 3.50 (3.09 to 3.96)‡ | 3.13 (2.46 to 3.99)‡ |
| Comorbidity | ||||||||||
| No | 133 | 1.51 | 26 | 2.42 | 1.61 (1.42 to 1.82)‡ | 1.78 (1.17 to 2.72)§ | 13 | 2.01 | 1.33 (1.12 to 1.58)‡ | 1.49 (0.84 to 2.64) |
| Yes | 281 | 5.20 | 28 | 3.98 | 0.77 (0.63 to 0.94)§ | 0.82 (0.55 to 1.21) | 259 | 22.7 | 4.36 (4.00 to 4.76)‡ | 4.48 (3.78 to 5.30)‡ |
*Incidence rate per 1000 person-years.
†Multiple analyses including age, sex, and comorbidities of hypertension, diabetes, hyperlipidaemia, coronary artery disease, heart failure, cancer, stroke, and lower leg fracture or surgery.
‡P<0.001.
§P<0.01.
IRR, incidence rate ratio.