Table 1

Study population in the UK Biobank, restricted to those with data on prescriptions

DemographicAll,
N=380 380
COVID-19 diagnosis, N=26 033No COVID-19 diagnosis, N=354 347COVID-19-related death, N=820No COVID-19-related death, N=379 560
<60 years of age, n(%)69 849 (18.36)7937 (30.49)61 912 (17.47)26 (3.17)69 823 (18.4)
60–70 years of age, n(%)120 013 (31.55)8568 (32.91)111 445 (31.45)129 (15.73)119 884 (31.58)
70–75 years of age, n(%)90 627 (23.83)4569 (17.55)86 058 (24.29)171 (20.85)90 456 (23.83)
>75 years of age, n(%)99 891 (26.26)4959 (19.05)94 932 (26.79)494 (60.24)99 397 (26.19)
Female sex, n(%)211 363 (55.57)13 802 (53.02)197 561 (55.75)286 (34.88)211 077 (55.61)
White British, n(%)357 620 (94.02)23 807 (91.45)333 813 (94.21)744 (90.73)356 876 (94.02)
Black British, n(%)9826 (2.58)1021 (3.92)8805 (2.48)36 (4.39)9790 (2.58)
Asian British, n(%)7329 (1.93)732 (2.81)6597 (1.86)25 (3.05)7304 (1.92)
Other ethnicity, n(%)5605 (1.47)473 (1.82)5132 (1.45)15 (1.83)5590 (1.47)
Prescribed methotrexate only, n(%)174 (0.05)11 (0.04)163 (0.05)0 (0)174 (0.05)
Prescribed folic acid only, n(%)12 433 (3.27)1273 (4.89)11 160 (3.15)120 (14.63)12 313 (3.24)
Prescribed methotrexate and folic acid, n(%)3952 (1.04)287 (1.1)3665 (1.03)11 (1.34)3941 (1.04)
Prescribed neither methotrexate nor folic acid, n(%)363 821 (95.65)24 462 (93.97)339 359 (95.77)689 (84.02)363 132 (95.67)
Rheumatoid arthritis, n(%)999 (0.26)97 (0.37)902 (0.25)8 (0.98)991 (0.26)
Sickle cell disease, n(%)517 (0.14)51 (0.2)466 (0.13)2 (0.24)515 (0.14)
Prescribed anticonvulsant medication, n(%)1642 (0.43)120 (0.46)1522 (0.43)10 (1.22)1632 (0.43)
Prescribed statins, n(%)156 064 (41.03)10 398 (39.94)145 666 (41.11)521 (63.54)155 543 (40.98)
Prescribed iron supplements, n(%)18 471 (4.86)1661 (6.38)16 810 (4.74)106 (12.93)18 365 (4.84)
Body mass index, mean(SD)27.41 (4.76)28.12 (5.03)27.35 (4.74)30.21 (5.79)27.4 (4.76)
Townsend deprivation index, mean (SD)−1.35 (3.04)−0.9 (3.18)−1.39 (3.03)−0.28 (3.4)−1.36 (3.04)
Never smoked, n(%)210 993 (55.47)13 990 (53.74)197 003 (55.6)321 (39.15)210 672 (55.5)
Current smoker, n(%)132 222 (34.76)9262 (35.58)122 960 (34.7)384 (46.83)131 838 (34.73)
Former smoker, n(%)37 165 (9.77)2781 (10.68)34 384 (9.7)115 (14.02)37 050 (9.76)
  • Association with a diagnosis of COVID-19.