Table 1

Enrolment, interventions and assessments

	Study period
	Enrolment	Pre-allocation		Allocation	Post-allocation			Close-out
Content	Screening and baseline assessment	Oocyte retrieval	Embryo culture	Blastocysts vitrification and randomisation	Embryo transfer	Evaluation of pregnancy	Follow-up of pregnancy
Time point	T0	T1	T2	T3	T4	T5	T6	T7
Time point	−3 month	−1 month	−1 weeks	0 day	2–6 months	3–7 months	6–10 months	12 months
Enrolment
Eligibility	×	×	×
Informed consent	×	×
Allocation				×
Interventions
NICS+morphology				×
Morphology				×
Assessments
Baseline data	×	×
Laboratory tests	×	×			×	×	×	×
Fertilisation			×
Embryo quality			×		×
Pregnancy tests						×
Pregnancy outcomes							×	×
Fetus information							×	×
Neonate information							×	×
Safety assessment	×	×			×	×	×	×