Table 1

Enrolment, interventions and assessments

Study period
EnrolmentPre-allocationAllocationPost-allocationClose-out
ContentScreening and baseline assessmentOocyte retrievalEmbryo cultureBlastocysts vitrification and randomisationEmbryo transferEvaluation of pregnancyFollow-up of pregnancy
Time pointT0T1T2T3T4T5T6T7
−3 month−1 month−1 weeks0 day2–6 months3–7 months6–10 months12 months
Enrolment
 Eligibility×××
 Informed consent××
 Allocation×
Interventions
 NICS+morphology×
 Morphology×
Assessments
 Baseline data××
 Laboratory tests××××××
 Fertilisation×
 Embryo quality××
 Pregnancy tests×
 Pregnancy outcomes××
 Fetus information××
 Neonate information××
 Safety assessment××××××
  • NICS, non-invasive chromosome screening.