Table 1

Study intervention on pregnant women, following the SPIRIT guideline recommendations

Time pointStudy period
EnrolmentRandomisationPostrandomisation
Screening0ANC1 (0−13 weeks+6 days)ANC2 (14–27 weeks+6 days)ANC3 (28–35 weeks+6 days)ANC4
(36–38 weeks)		Delivery28-day newborn assessment
Enrolment        
 Informed consentX       
 Eligibility screeningX       
 Randomisation X      
Arms        
 Standard of care (S)Embedded Image
 Intervention (I)Embedded Image
Assessments        
 Obstetric ultrasoundS, I       
 Haemoglobin test  S, IS, IS, IS, IS, I 
 Malaria test with microscopy  I, S*I, S*I, S*I, S*I, S* 
 Malaria test with RDT  IIIII 
 Malaria test with LAMP  IIIII 
 Sample storage  S, IS, IS, IS, IS, I 
 Newborn assessment      S, IS, I
 Newborn weight      S, IS, I
 Placenta weight      S, I 
 Placenta blood smear      S, I 

  • *Only women symptomatic in the standard of care arm.

  • ANC, antenatal care; LAMP, loop-mediated isothermal amplification; RDT, rapid diagnostic test; SPIRIT, Standard Protocol Items: Recommendations for Interventional Trials.