Table 3

Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial dose titration schedule

Baseline (week 0)
‘quarter dose’:
2.5 mL
Week 1
‘half dose’:
5 mL
Week 2
‘three quarter dose’:
7.5 mL
Week 3
‘full dose’:
10 mL
Memantine5 mg10 mg15 mg20 mg
Trazodone50 mg100 mg150 mg200 mg
Placebo2.5 mL5 mL7.5 mL10 mL