Table 1

Participant timeline

Study period
 TimepointsEnrolmentAllocationIn-hospitalPostoperative follow-up
Preoperative−8 weeks−1 days0.5 hours2 hours4 hours8 hours24 hours48 hours3 days4 days5 days7 days1 month3 months6 months12 months
Enrolment
 Eligibility screeningX                
 Informed consentX                
 Random allocation X               
Interventions
 Baseline dataXX               
 Fluoxetine X               
Assessments
 MMSEX                
 Neuropsychological evaluationX            XXXX
 Postoperative delirium   XXXXXXXXX     
 AUC of the NRS at rest   XXXXXX        
 AUC of the NRS on movement   XXXXXX        
 Sleep disturbance  X         XX   
 QoR-15  X    X    XX   
 Anxiety and depression  X         XX   
 Postoperative opioid consumption       X         
 CRP  XX             
 IL-1β  XX             
 Adverse events   XXXXXXXXXX    

  • AUC, area under the curve; CRP, C reactive protein; IL, interleukin; MMSE, Mini-Mental State Examination; NRS, Numeric Rating Scale; QoR-15, 15-item Quality of Recovery.