Table 2

Sensitivity and specificity with respective CIs for detecting different biomarkers with SELFF-OCT and for the decision for anti-VEGF treatment based on SELFF-OCT imaging

Sensitivity (95% CI)Specificity (95% CI)Number of occurrences
Drusen1.0 (0.94 to 1)1.0 (0.16 to 1)71/73
Pigment epithelium detachment0.76 (0.59 to 0.89)0.95 (0.83 to 0.99)37/73
Subretinal fluid (SRF)0.9 (0.73 to 0.98)0.98 (0.89 to 1.0)29/73
Intraretinal fluid (IRF)0.57 (0.29 to 0.82)0.95 (0.86 to 0.99)14/73
SRF or IRF0.92 (0.78 to 0.98)0.97 (0.86 to 1.0)36/73
Intraretinal hyper-reflective foci0.68 (0.48 to 0.84)0.8 (0.65 to 0.9)28/73
Need for anti-VEGF treatment0.94 (0.79 to 0.99)0.95 (0.82 to 0.99)32/69
  • Number of occurrences shows in how many eyes the respective biomarker was present in SD-OCT.

  • SD-OCT, spectral-domain OCT; SELFF-OCT, Self-Examination Low-Cost Full-Field Optical Coherence Tomography; VEGF, vascular endothelial growth factor.