Table 2

Study timeline for adult patients with inflammatory bowel diseases

Time pointTime of diagnosisDuring the first year after diagnosisAt 12 months of follow-upDuring the second year after diagnosisAt 24 months of follow-upDuring years 3–5 after diagnosis:At 60 months of follow-upYears 6–20
Frequency of visitMinimum every third month and at eventsMinimum every 6 months and at events Minimum annually and at eventsMinimum annually and at events
Screening for inclusionX  
Participant information and written informed consentX  
Collection of information from medical record including any medical adverse eventsXXXX XXX
Detailed environmental questionnaireX  
Collection of purchase dataXXXX XX 
Clinical disease activity scoreXXXX XX 
Collection of faecal sample and rectal swabXXXX XX 
Collection of blood sampleXXXX XX 
Collection of saliva sampleXXXXXXX 
Collection of biopsies at endoscopyX(X)X(X) (X)(X) 
MR cholangio-pancreatographyX X 
MR enterographyXX (X)X 
Rheumatological assessmentX(X) X 
MRI of spine and sacroiliac jointsX(X) (X) 
US of peripheral joints end enthesesX(X) (X) 
Dermatological assessment(X)(X)(X)(X) (X)(X) 
DXA scanX X 
IUSX(X)X XX 
FibroscanAt sign of liver diseaseAt sign of liver disease  
Dental assessmentXXXX 
Panoramic radiographX X 
Collection of dental treatment needsXXXXXXXX

  • (X) indicates that the investigation will be performed if clinically relevant. MR enterography will be performed after 5 years in patients with CD. Fibroscan will be performed if a FIB4 calculation is greater than 1.45.

  • CD, Crohn’s disease; DXA, dual-energy X-ray absorptiometry; IUS, intestinal ultrasound.