Treatment time in young and old patients with ischaemic stroke treated with IV tPA
| Measures | Total (n=48 141 (100%)) | Young adults (<50 years) (n=5044 (10.5%)) | Old adults (≥50 years) (n=43 097 (89.5%)) | ASD (%)/H-L estimator* |
| Onset-to-needle time†, hour | 2.7 (2.0–3.5) | 2.7 (2.0–3.5) | 2.7 (2.0–3.5) | |
| DNT‡, min | 60.0 (36.0–84.0) | 60.0 (42.0–90.0) | 60.0 (36.0–84.0) | |
| Treatment time | ||||
| DNT ≤30 min | 8938 (18.6) | 850 (16.9) | 8088 (18.8) | 5.0 |
| DNT ≤45 min | 15 637 (32.5) | 1521 (30.2) | 14 116 (32.8) | 5.6 |
| DNT ≤60 min | 25 884 (53.8) | 2531 (50.2) | 23 353 (54.2) | 8.0 |
*H-L estimator; an absolute standardised difference (%) >10% indicates meaningful imbalance between two groups.
†Onset-to-needle time was missing for 3818 (7.9%) patients, with 431 (8.5%) in age <50 years and 3387 (7.9%) in age ≥50 years groups.
‡DNT was missing for 3027 (6.3%) patients, with 342 (6.8%) in age <50 years and 2685 (6.2%) in age ≥50 years groups.
ASD, absolute standardised difference; DNT, door-to-needle time; H-L, Hodges-Lehmann; IV tPA, intravenous tissue plasminogen activator.