Table 1

Descriptive summary of different research questions and study requirements

S/n	Research question	Endpoint	Required variables	Proposed analysis method
1.	What is the prevalence and incidence of DM/ hyperglycaemia in patients receiving treatment for tuberculosis in Eswatini?	Prevalence of DM in diagnosed patients with TB Identified risk factors Incidence of elevated blood glucose in those receiving treatment for TB Identified predictive factors	Sociodemographic variables Clinical variables Baseline and follow-up data	Descriptive: Frequency tables with percentages, Mean (SD) and/or median (IQR) Comparative analysis: Pearson χ2 test or Fischer’s exact test for categorical variables. T-test or Mann-Whitney for continuous variables. Statistical analysis: Univariate and multivariate logistic regression and mixed-effects model. Missing data: If ≥10%, imputation of missing data will be done, and the results averaged across all the datasets imputed. Sensitivity analysis: Nested multilevel logistic regression analysis with random effects at two levels (region and individual) to account for clustering at regions. Model Fitness: Hosmer-Lemeshow goodness of fit test
2.	Does DM or hyperglycaemia affect TB treatment outcome in patients receiving treatment for tuberculosis in Eswatini?	Findings of comparative analysis of TB treatment outcome in patients with diabetics/ hyperglycaemia and those without	Sociodemographic variables Clinical variables Baseline and follow-up data	Descriptive: Frequency tables with percentages, Mean (SD) and median (IQR) Comparative analysis: Pearson χ2 or Fischer’s exact test for categorical variables. T-test or Mann Whitney for continuous variables. Statistical analysis: Univariate and multivariate logistic or linear regression models. Missing data: If ≥10%, imputation of missing data will be done, and the results averaged across all the datasets imputed. Model Fitness: Hosmer-Lemeshow goodness of fit test, residual sum of squares
3.	What factors limit the effective integration of diabetes care into TB Services provision at the health facilities providing TB care in Eswatini?	Identified factors Recommendations for effective services delivery	All the variables from the qualitative questionnaire	Descriptive: Frequency tables with percentages, Mean (SD) and median (IQR) Qualitative analysis: Analysis of both deductive and inductive codes from healthcare worker’s interviews.

DM, diabetes mellitus; TB, tuberculosis.