Clinical characteristics and demographics of non-invasive prenatal testing (NIPT) versus no NIPT groups
| NIPT (n=551) | No-NIPT (n=1506) | P value* | |
| Demographic information | |||
| Age, mean (SD) | 37.23 (2.25) | 37.41 (2.42) | 0.11† |
| Grouped age (three groups) | 0.17 | ||
| 35–39 | 468 (84.94) | 1236 (82.07) | |
| 40–44 | 80 (14.52) | 251 (16.67) | |
| 45 ≤ | 3 (1.26) | 19 (0.54) | |
| Grouped age (two groups) | 0.13 | ||
| 35–39 | 468 (84.94) | 1236 (82.07) | |
| 40 ≤ | 83 (15.06) | 270 (17.93) | |
| Health plan | <0.01 | ||
| Commercial insurance | 547 (99.27) | 1196 (79.42) | |
| Government | 0 (0) | 3 (0.20) | |
| Medicaid | 2 (0.36) | 270 (17.93) | |
| Medicare | 2 (0.36) | 20 (1.33) | |
| Other Insurance/unknown | 0 (0) | 17 (1.13) | |
| Health plan—two grouped | <0.01 | ||
| Commercial | 547 (99.27) | 1196 (79.42) | |
| All non-commercial | 4 (0.73) | 310 (20.58) | |
| Clinical characteristics and risk factors | |||
| Insufficient prenatal care | 4 (0.73) | 22 (1.46) | 0.18 |
| Social problem | 16 (2.9) | 15 (1.00) | <0.01 |
| Genitourinary infection | 58 (10.53) | 180 (11.95) | 0.37 |
| Gestational diabetes | 64 (11.62) | 284 (18.86) | <0.01 |
| Grand multiparity | 0 | 0 | n/a |
| Hypothyroidism | 90 (16.33) | 216 (14.34) | 0.26 |
| Substance abuse/alcohol abuse | 7 (1.27) | 94 (6.24) | <0.01 |
| Overweight/obese | 156 (28.31) | 543 (36.06) | <0.01 |
| Hypertension | 73 (13.25) | 268 (17.80) | 0.01 |
| IPD during the 90-day follow-up | 16 (2.90) | 40 (2.66) | 0.76 |
*P value from χ2 test or Fisher’s exact test if an expected count of patient is less than five from a tabulate analysis.
†P value from Student’s t-test.
IPD, invasive prenatal diagnostic testing including amniocentesis and chorionic villus sampling.