Variable | Crude | Adjusted log 3-month MPR | Adjusted log 6-month MPR | Adjusted log 1-year MPR | ||||||||
OR | 95% CI | P value | OR | 95% CI | P value | OR | 95% CI | P value | OR | 95% CI | P value | |
Medication adherence | ||||||||||||
log 3-month MPR | 0.8 | 0.78 to 0.83 | <0.001 | 0.78 | 0.75 to 0.81 | <0.001 | ||||||
log 6-month MPR | 0.72 | 0.7 to 0.74 | <0.001 | 0.72 | 0.69 to 0.75 | <0.001 | ||||||
log 1-year MPR | 0.69 | 0.67 to 0.71 | <0.001 | 0.7 | 0.68 to 0.72 | <0.001 | ||||||
Age | 1.04 | 1.03 to 1.05 | <0.001 | 1.03 | 1.02 to 1.04 | <0.001 | 1.03 | 1.02 to 1.04 | <0.001 | 1.03 | 1.02 to 1.04 | <0.001 |
Complications | ||||||||||||
Varicose vein bleeding | 6 | 4.2 to 8.83 | <0.001 | 6.57 | 4.53 to 9.52 | <0.001 | 6.71 | 4.62 to 9.76 | <0.001 | 6.65 | 4.57 to 9.68 | <0.001 |
Ascites | 6.73 | 5.9 to 7.67 | <0.001 | 6.58 | 5.76 to 7.5 | <0.001 | 6.55 | 5.74 to 7.48 | <0.001 | 6.47 | 5.66 to 7.4 | <0.001 |
SBP | 7.41 | 5.28 to 10.4 | <0.001 | 7.22 | 5.12 to 10.2 | <0.001 | 6.93 | 4.89 to 9.81 | <0.001 | 6.71 | 4.73 to 9.54 | <0.001 |
HRS | 12.5 | 7.17 to 21.9 | <0.001 | 12.7 | 7.18 to 22.5 | <0.001 | 12 | 6.71 to 21.4 | <0.001 | 11.3 | 6.3 to 20.4 | <0.001 |
HE | 9.18 | 7.76 to 10.9 | <0.001 | 8.98 | 7.58 to 10.6 | <0.001 | 8.71 | 7.34 to 10.3 | <0.001 | 8.45 | 7.11 to 10 | <0.001 |
Two or more | 15.7 | 13.5 to 18.2 | <0.001 | 16.1 | 13.8 to 18.7 | <0.001 | 16.2 | 13.9 to 18.8 | <0.001 | 16 | 13.7 to 18.6 | <0.001 |
None | 1 | 1 | 1 | 1 | ||||||||
NUCs | ||||||||||||
LAM | 0.71 | 0.61 to 0.82 | <0.001 | 0.71 | 0.59 to 0.85 | <0.001 | 0.71 | 0.59 to 0.86 | <0.001 | 0.74 | 0.61 to 0.89 | <0.001 |
ADV | 0.55 | 0.39 to 0.77 | <0.001 | 0.65 | 0.43 to 0.97 | 0.04 | 0.68 | 0.45 to 1.03 | 0.07 | 0.75 | 0.49 to 1.15 | 0.18 |
LdT | 0.84 | 0.71 to 1 | 0.04 | 1 | 0.82 to 1.23 | 0.99 | 1.03 | 0.84 to 1.27 | 0.75 | 1.08 | 0.88 to 1.33 | 0.46 |
ETV | 0.62 | 0.54 to 0.7 | <0.001 | 0.72 | 0.62 to 0.84 | <0.001 | 0.74 | 0.63 to 0.86 | <0.001 | 0.77 | 0.66 to 0.91 | <0.001 |
TDF | 0.29 | 0.25 to 0.34 | <0.001 | 0.41 | 0.34 to 0.49 | <0.001 | 0.43 | 0.36 to 0.51 | <0.001 | 0.45 | 0.37 to 0.54 | <0.001 |
Two or more treatments | 1 | 1 | 1 | 1 |
ADV, adefovir dipivoxil; ETV, entecavir; HE, hepatic encephalopathy; HRS, hepatorenal syndrome; LAM, lamivudine; LdT, telbivudine; MPR, medication possession ratio; NUCs, nucleos(t)ide analogues; SBP, spontaneous bacterial peritonitis; TDF, tenofovir disoproxil fumarate.