Table 4

Temporal trends in GDMT by discharge among the entire cohort and by TIMI risk score for secondary prevention (TRS2°P)


n (%)
Entire cohortHigh-risk
(TRS2°P=3)
Very high-risk
(TRS2°P=4)
Extremely high-risk (TRS2°P≥5)
Early
(n=2737)
Late
(n=2622)
P-valueEarly
(n=1404)
Late
(n=1306)
P-valueEarly
(n=777)
Late
(n=780)
P-valueEarly
(n=556)
Late
(n=536)
P-value
PCI1256 (45.9)1583 (60.4)<0.001739 (52.6)869 (66.5)<0.001324 (41.7)461 (59.1)<0.001193 (34.7)253 (47.2)<0.001
Total angiographies1427 (69.9)2228 (85)<0.001806 (78.5)1192 (91.3)<0.001366 (64)646 (82.8)<0.001255 (57.6)390 (72.8)<0.001
Composite intervention*829 (32.9)1397 (53.8)<0.001492 (38.6)781 (60.4)<0.001205 (28.7)403 (52.3)<0.001132 (25)213 (40)<0.001
Aspirin2385 (89.4)2365 (93.4)<0.0011241 (90)1221 (95.5)<0.001676 (89.7)696 (93.2)0.019468 (87.3)448 (88.5)0.6
Prasugrel0 (0)323 (12.4)<0.0010 (0)218 (16.8)<0.0010 (0)85 (11)<0.0010 (0)20 (3.8)<0.001
Ticagrelor0 (0)615 (23.7)<0.0010 (0)344 (26.5)<0.0010 (0)177 (22.8)<0.0010 (0)94 (18)<0.001
Clopidogrel1887 (69.2)1514 (58.3)<0.0011021 (73)679 (52.3)<0.001500 (64.4)469 (60.4)<0.001366 (66.3)366 (70.1)<0.001
Any P2Y12 inhibitor1887 (69.2)2452 (94.4)<0.0011021 (73.0)1241 (95.5)<0.001500 (64.4)731 (94.2)<0.001366 (66.3)480 (92.0)<0.001
Anticoagulants157 (5.9)295 (12.8)<0.00164 (4.7)106 (9.2)<0.00143 (5.7)105 (15.0)<0.00150 (9.4)84 (18.1)<0.001
Statins2063 (77.3)2370 (95)<0.0011077 (78.2)1210 (96)<0.001577 (76.5)694 (94.4)<0.001409 (76.2)466 (93)<0.001
ACEi/ARBs1997 (74.8)1989 (82)<0.0011048 (76)1051 (85.6)<0.001570 (75.6)594 (82.6)0.001379 (70.7)344 (72)0.7
Beta blockers2047 (76.6)2018 (82.1)<0.0011046 (75.7)1026 (82.8)<0.001594 (78.9)592 (81.2)0.29407 (75.8)400 (81.6)0.028
Cardiac rehabilitation referral at 30-day FUP338 (28.6)981 (46.7)<0.001184 (30.4)544 (50.5)<0.00189 (29)292 (47.5)<0.00165 (24.3)145 (35.6)0.003
  • *Composite intervention was defined as DAPT and statins at discharge and PCI during hospitalisation.

  • ACEI, angiotensin-converting enzyme inhibitors; ARBs, angiotensin receptor blockers; DAPT, dual antiplatelet therapy; FUP, follow-up; GDMT, guideline-directed medical treatment; PCI, percutaneous coronary intervention; TIMI, Thrombolysis in Myocardial Infarction.