The univariate analysis of 5-year survival prognostic factors in lung adenocarcinoma patients
| Variable | Univariate analysis | |
| P value＞│z│ | HR (95% CI) | |
| Tumour budding (10 HPF) | ||
| Low (n=141) vs high (n=193) | 0.011* | 1.374 (1.077 to 1.753) |
| Nuclear size | ||
| Small (n=145) vs large (n=189) | 0.023* | 1.467 (1.054 to 2.042) |
| Smallest tumour cell nest | ||
| Single cell (n=166) vs 2–4cells (n=168) | 0.699 | 0.943 (0.702 to 1.267) |
| Gender | ||
| Male (n=208) vs female (n=172) | 0.252 | 0.835 (0.614 to 1.136) |
| Age(years) | ||
| ≤65 (n=150) vs＞65 (n=228) | 0.050 | 1.362 (1.00 to 1.854) |
| Pleural invasion | ||
| Absent (n=151) vs present (n=229) | 0.021* | 1.560 (1.071 to 2.272) |
| Vascular invasion | ||
| Absent (n=179) vs present (n=201) | 0.001* | 2.357 (1.401 to 3.965) |
| STAS | ||
| Absent (n=102) vs present (n=278) | <0.001* | 2.874 (1.690 to 4.887) |
| Necrosis | ||
| Absent (n=114) vs present (n=266) | 0.047* | 1.315 (1.004 to 1.722) |
| Histological subtype | ||
| Adherent type (n=63) vs acinar type (n=140) vs papillary type (n=49) vs micropapillary type (n=62) vs solid type (n=66) | 0.014* | 0.858 (0.759 to 0.969) |
| Interstitial fibrosis | ||
| Absent(n=11) vs present(n=369) | 0.200 | 0.900 (0.766 to 1.057) |
| pT | ||
| pT1 +pT2(n=295) vs pT3 +pT4 (n=85) | <0.001* | 2.069 (1.687 to 2.538) |
| pN | ||
| pN0(n=195) vs pN1 +pN2+pN3 (n=185) | <0.001* | 1.974 (1.363 to 2.858) |
| TNM stage | ||
| Ⅰ+ Ⅱ(n=273) vs Ⅲ+ Ⅳ(n=107) | 0.003* | 0.484 (0.301 to 0.780) |
*P＜0.05
HPF, high-power field; STAS, spread through air spaces; TNM, tumour node metastasis.