Table 1

Inclusion and exclusion criteria of the observational cohort study and feasibility randomised controlled trial

Inclusion criteriaExclusion criteria
Observational cohort study
Aged 65 years or olderUnable to provide informed consent
Admitted to geriatric rehabilitationPatients in isolation/quarantine
Written informed consentAny condition that prevents completion of the study
Palliative care
Not possible to communicate in Dutch
Feasibility randomised controlled trial
Aged 65 years or olderUnable to provide informed consent and no proxy to consent
Admitted to geriatric rehabilitationRehabilitation after stroke or cancer
Diagnosed with sarcopenia (EWGSOP2 definition)Patients in isolation/quarantine
Written informed consentPalliative care or other adverse prognosis precluding post-intervention follow-up
Ongoing cancer treatment or radiotherapy/ chemotherapy in the last 6 months
Any GI disease that interferes with bowel function and nutritional intake
Other relevant medical history or medication that could prevent participation in the
intervention or affect the study outcome
Patients with tube feeding at admission to geriatric rehabilitation.
Renal impairment (estimated glomerular filtration rate <30 mL/min/1.73 m2)
Body mass index >40 kg/m2
Known soy allergy, known cow’s milk protein allergy or galactosaemia, known severe
Lactose intolerance; patients requiring a fibre-free diet
Current alcohol or drug abuse in opinion of the investigator
Not possible to communicate in Dutch
Uncertainty about the willingness/ability of the subject to comply with the protocol
Participation in other intervention studies
For BIA measurements only: electronic implant and/or pacemaker*
  • *Our aim is to assess muscle mass in minimum 60 participants. Therefore, a maximum of 20 patients with an electronic implant/pacemaker will be included in the study.

  • BIA, bioelectrical impedance analysis; EWGSOP, European Working Group on Sarcopenia in Older People; GI, gastrointestinal.