Table 1

Characteristics of included trials using an MAMS protocol approach

Category	No of MAMS trials	Percentage of MAMS trials
Disease area
Infection	32	52
Cancer	18	29
Neurology	4	6
Mental health	2	3
Diabetes	2	3
Dermatology	1	2
Haematology	1	2
Inflammation	1	2
Surgery	1	2
MAMS term used
Yes	31	50
No	31	50
Phase of trial
Seamless phase 2/3	33	53
Phase 3	29	47
Organisation leading trial
Non-commercial	55	89
Commercial	7	11
Country of organisation leading trial
UK	26	41
USA	20	32
France	5	8
Switzerland	2	3
Australia	1	2
Austria	1	2
Brazil	1	2
Canada	1	2
Denmark	1	2
Netherlands	1	2
Pakistan	1	2
Singapore	1	2
Spain	1	2