PAD | PAD with existing CVD | |||
Female (n=13 343) | Male (n=24 963) | Female (n=3509) | Male (n=8551) | |
Age (IQR) | 76.0 (67.0–83.0) | 73.0 (66.0–80.0) | 78.0 (70.0–84.0) | 75.0 (68.0–82.0) |
Age categories (%) | ||||
41–50 | 353 (2.6) | 468 (1.9) | 32 (0.9) | 57 (0.7) |
51–60 | 1107 (8.3) | 2351 (9.4) | 195 (5.6) | 492 (5.8) |
61–70 | 2709 (20.3) | 7027 (28.1) | 579 (16.5) | 1967 (23.0) |
71–80 | 4170 (31.3) | 8732 (35.0) | 1140 (32.5) | 3217 (37.6) |
81< | 5004 (37.5) | 6385 (25.6) | 1563 (44.5) | 2818 (33.0) |
Townsend (%) | ||||
1 (least deprived) | 1809 (13.6) | 3835 (15.4) | 406 (11.6) | 1342 (15.7) |
2 | 2226 (16.7) | 4402 (17.6) | 572 (16.3) | 1457 (17.0) |
3 | 2442 (18.3) | 4742 (19.0) | 674 (19.2) | 1634 (19.1) |
4 | 2759 (20.7) | 4522 (18.1) | 724 (20.6) | 1562 (18.3) |
5 (most deprived) | 2157 (16.2) | 3768 (15.1) | 617 (17.6) | 1274 (14.9) |
Missing | 1950 (14.6) | 3694 (14.8) | 516 (14.7) | 1282 (15.0) |
BMI (IQR) | 26.0 (22.0–30.0) | 27.0 (24.0–30.0) | 26.0 (23.0–30.0) | 27.0 (24.0–30.0) |
BMI categories (%) | ||||
Underweight (<18.5) | 599 (4.5) | 417 (1.7) | 146 (4.2) | 112 (1.3) |
Normal weight (18.5–25) | 4531 (34.0) | 6821 (27.3) | 1111 (31.7) | 2171 (25.4) |
Overweight (25–30) | 4157 (31.2) | 9868 (39.5) | 1138 (32.4) | 3477 (40.7) |
Obese class 1 (30–35) | 2232 (16.7) | 5016 (20.1) | 640 (18.2) | 1872 (21.9) |
Obese class 2/3 (>35) | 1330 (10.0) | 1959 (7.8) | 365 (10.4) | 721 (8.4) |
Missing | 494 (3.7) | 882 (3.5) | 109 (3.1) | 198 (2.3) |
Smoker categories (%) | ||||
Non-smoker | 4499 (33.7) | 5228 (20.9) | 1269 (36.2) | 1881 (22.0) |
Discontinued | 5362 (40.2) | 13 070 (52.4) | 1464 (41.7) | 4904 (57.4) |
Smoker | 3468 (26.0) | 6640 (26.6) | 774 (22.1) | 1760 (20.6) |
Missing | 14 (0.1) | 25 (0.1) | (n<5) | 6 (0.1) |
Chronic kidney disease stages (%) | ||||
Stage 1 (>90 mL/min) | 1604 (12.0) | 4323 (17.3) | 283 (8.1) | 943 (11.0) |
Stage 2 (60–89 mL/min) | 6425 (48.2) | 12 416 (49.7) | 1542 (43.9) | 4137 (48.4) |
Stage 3 (45–59 mL/min) | 4383 (32.8) | 6786 (27.2) | 1365 (38.9) | 2936 (34.3) |
Stage 4 (15–29 mL/min) | 676 (5.1) | 863 (3.5) | 265 (7.6) | 393 (4.6) |
Stage 5 (<15 mL/min) | 77 (0.6) | 194 (0.8) | 30 (0.9) | 95 (1.1) |
Missing | 178 (1.3) | 381 (1.5) | 24 (0.7) | 47 (0.5) |
Charlson Comorbidity Index (%) | ||||
0 | 3245 (24.3) | 5681 (22.8) | 730 (20.8) | 1837 (21.5) |
1 | 2383 (17.9) | 4433 (17.8) | 754 (21.5) | 1826 (21.4) |
2 | 2016 (15.1) | 3846 (15.4) | 623 (17.8) | 1476 (17.3) |
3 | 1194 (8.9) | 2339 (9.4) | 488 (13.9) | 1199 (14.0) |
4 | 1345 (10.1) | 2987 (12.0) | 654 (18.6) | 1667 (19.5) |
5 or more | 1345 (10.1) | 2987 (12.0) | 654 (18.6) | 1667 (19.5) |
1-year mortality | 1019 (7.6) | 1656 (6.6) | 350 (10.0) | 705 (8.2) |
Medical conditions (%) | ||||
Diabetes (insulin and non-insulin dependent) | 3670 (27.5) | 7874 (31.5) | 1223 (34.9) | 3183 (37.2) |
Hypertension | 8582 (64.3) | 14 945 (59.9) | 2463 (70.2) | 5382 (62.9) |
Stroke and TIA | 2542 (19.1) | 4595 (18.4) | 1556 (44.3) | 3070 (35.9) |
Ischaemic heart disease | 3752 (28.1) | 9536 (38.2) | 2520 (71.8) | 6989 (81.7) |
Heart failure | 1049 (7.9) | 2524 (10.1) | 631 (18.0) | 1733 (20.3) |
Atrial fibrillation | 1705 (12.8) | 3770 (15.1) | 705 (20.1) | 1916 (22.4) |
Drugs-recent prescriptions (within 3 months) (%) | ||||
Statins | 9064 (67.9) | 18 729 (75.0) | 2701 (77.0) | 7250 (84.8) |
Clopidogrel | 2163 (16.2) | 4184 (16.8) | 746 (21.3) | 1839 (21.5) |
Aspirin | 6176 (46.3) | 12 373 (49.6) | 1852 (52.8) | 4830 (56.5) |
Anticoagulation | 1649 (12.4) | 3404 (13.6) | 598 (17.0) | 1658 (19.4) |
Alpha adrenoceptor blockers | 767 (5.7) | 1617 (6.5) | 206 (5.9) | 552 (6.5) |
ACE inhibitors | 4030 (30.2) | 9756 (39.1) | 1308 (37.3) | 4188 (49.0) |
Angiotensin receptor blockers | 2139 (16.0) | 3348 (13.4) | 666 (19.0) | 1427 (16.7) |
Beta blockers | 3903 (29.3) | 8246 (33.0) | 1695 (48.3) | 4551 (53.2) |
Calcium channel blockers | 4491 (33.7) | 8416 (33.7) | 1287 (36.7) | 2957 (34.6) |
Diuretic | 4637 (34.8) | 6880 (27.6) | 1516 (43.2) | 3076 (36.0) |
Renin inhibitors | (n<5) | (n<5) | – | (n<5) |
Surgery (%) | ||||
Previous lower limb bypass | 1510 (11.3) | 3161 (12.7) | 338 (9.6) | 889 (10.4) |
ACE, angiotensin converting enzyme inhibitors; BMI, body mass index; Min, minutes; mL, millilitres; TIA, Transient ischaemic attack.