Table 1

Overview of the sample size calculations for Hb; ferritin; adverse events; mental health; physical health

Iron supplementationPlaceboRequired sample sizeSufficiency
Hb134 (11) g/L120 (12) g/L19Sufficient
Ferritin28.0 (9.8) µg/L12.9 (8.3) µg/L14Sufficient
Adverse events*39.2%15.5%144Sufficient
Mental health†40.1 (4.8)40.7 (4.8)2016Not sufficient
Physical condition†54.8 (3.3)52.4 (5.2)60Sufficient
  • *Adverse events included gastrointestinal symptoms, dizziness, headache, acne, palpitations and renal lithiasis.

  • †The outcome parameter mental health and physical condition were based on construct scores from the 12-Item Short Form Survey (SF-12) .

  • Hb, haemoglobin.