Medication classes and specific drugs implicated in drug-related hospitalisation (DRH) in the emergency ward at TASH, ZMH and Y12HMC, Addis Ababa, Ethiopia, August–September 2020 (n=245)
Drug class | Specific drugs | n (%) |
Cardiovascular drugs | ||
Atorvastatin | 31 (12.7) | |
Antiplatelets (aspirin, clopidogrel) | 24 (9.8) | |
Furosemide | 59 (24.1) | |
Spironolactone | 33 (13.5) | |
Anticoagulants (warfarin, heparin) | 20 (8.2) | |
Beta-blockers (metoprolol, atenolol) | 21 (8.6) | |
Digoxin | 15 (6.1) | |
ACE inhibitors (enalapril/lisinopril) | 48 (19.6) | |
Calcium channel blockers (nifedipine, amlodipine) | 34 (13.9) | |
Hydrochlorothiazide | 11 (4.5) | |
Drugs for the respiratory system | ||
Long-acting beta-blockers | 15 (6.1) | |
Bronchodilator | 10 (4.1) | |
Central nervous system drugs | ||
Antiepileptics | 5 (2) | |
Antipsychotics | 5 (2) | |
Amitriptylin | 2 (0.8) | |
Antimicrobial drugs | ||
Antibiotics (piperacillin/tazobactam, meropenem, amoxicillin, amoxicillin/clavunicacid, ceftriaxone, benzathine penicillin) | 25 (10.2) | |
Combination of antiretroviral therapy | 15 (6.1) | |
Anti-tuberculosis | 13 (5.3) | |
Antineoplastic agents | Cyclophosphamide, imatinib, methotrexate, doxorubicin | 23 (9.4) |
Immunosuppressants | ||
Mycophenolate | 1(.4) | |
Corticosteroids (prednisolone, budesonide) | 9 (3.7) | |
Endocrine drugs | ||
Oral hypoglycaemic drugs (metformin, glibenclamide) | 37 (15.1) | |
Insulin | 24 (9.8) | |
Propylthiouracil | 4 (1.6) | |
Gastrointestinal drug | Proton pump inhibitors | 7 (2.9) |
Others | Potassium chloride | 1 (0.4) |
Non-steroidal anti-inflammatory drugs | 3 (1.2) | |
Opioids | 1 (0.4) | |
Others | ||
Ferrous sulfate | 1 (0.4) | |
Total number of medications involved in DRH | 497 | |
Total number of drug-related hospitalised participants | 245 (57.9) | |
Average number of medications per drug-related hospitalised patient | 2.03 |
TASH, Tikur Anbessa Specialized Hospital; Y12HMC, Yekatit 12 Hospital Medical College; ZMH, Zewditu Memorial Hospital.