Table 1

Patient demographics and disease characteristics

PredictorTreatment randomisation
RandomisedNot randomisedTotal
N%N%N%
Age
12–18627382751790255
<1227617117739324
>1821913117733621
Missing000000
Histological response*
Good
(<10% tumour) *
614382311484552
Poor
(≥10% tumour)
505312401574546
Missing30382413
Excision
Wide/radical9235740425132781
Marginal149955320413
Intralesional
Other
15170221
Unknown†11150161
Missing241382624
Volume‡
<200633393031993657
≥20026516126839124
Missing2241480530419
Sex
Female470292201369042
Male652402891894158
Missing000000
Tumour location§
Other9565941325136984
Proximal femur/humerus133874520713
Axial332221553
Missing000000
  • *A good and poor histological response are defined by the amount of tumour remaining after resection, with <10% and ≥10% constituting a good and poor response, respectively.

  • †A subset of patients had an excision marked as ‘unknown’. In the analysis, this category is treated as missing data and imputed.

  • ‡Absolute volume is measured in cm × cm × cm × 0.54 (spheric T vol), or 0.785 for cylindric T vol).

  • §Tumour location was defined in accordance with the definition used in the Smeland et al. (2019) analysis of survival and prognosis in the EURAMOS-1 trial. Information was pooled from study variables ‘site’ (eg, femur, pelvis, spine, etc) and ‘location’ (eg, proximal, axial, etc). Observed axial tumour locations included rib (14) and pelvis/sacrum (41).

  • EURAMOS-1, European and American Osteosarcoma Study.