Table 3

HR estimates from multistate model per transition, for all absorbent transitions from intermediate event to death

PredictorSurgery → deathLocal recurrence → deathNew metastatic disease → deathNew metastatic disease +local recurrence→deathNew metastatic disease 2 → death
HR95% CIHR95% CIHR95% CIHR95% CIHR95% CI
Age
12–1811111
<120.5550.368 to 0.8362.4011.517 to 3.7990.8810.757 to 1.0242.8381.825 to 4.4132.3351.694 to 3.218
>180.7390.506 to 1.0810.3450.213 to 0.5600.8920.785 to 1.0140.4730.314 to 0.7110.5290.338 to 0.829
Histological response
Good (<10% tumour)11111
Poor (≥10% tumour)1.5511.147 to 2.0991.7481.236 to 2.4711.4721.29 to 1.6792.4531.561 to 3.8550.8720.645 to 1.179
Time effect0.9790.967 to 0.992
Excision
Wide/radical111
Marginal0.3790.221 to 0.6511.0890.929 to 1.2770.8110.442 to 1.490
Intralesional0.3310.163 to 0.6731.4010.975 to 2.0145.2962.856 to 9.819
Location
Other111
Proximal femur/humerus2.2991.585 to 3.3352.7171.696 to 4.3541.3261.151 to 1.527
Axial6.9194.497 to 10.6511.5356.113 to 21.7671.3351.016 to 1.755
Sex
Female11111
Male0.9860.733 to 1.3261.3050.923 to 1.8441.5891.418 to 1.7821.8231.302 to 2.5521.1650.836 to 1.623
Volume
<20011111
≥2001.0930.772 to 1.5480.7560.516 to 1.1061.030.915 to 1.161.130.804 to 1.5890.8660.591 to 1.271
  • Bold values indicate hazard ratios (HRs) with 95% confidence intervals (CIs) that exclude the null.