Table 2

HR estimates from multistate model per transition, for all transitions from surgery to intermediate event

PredictorSurgery → local recurrenceSurgery → new metastatic diseaseSurgery → new metastatic disease +local recurrenceSurgery → secondary malignancyNew metastatic disease → new metastatic disease 2
HR95% CIHR95% CIHR95% CIHR95% CIHR95% CI
Age
12–1811111
<120.6620.509 to 0.8610.7980.724 to 0.880.8440.612 to 1.1650.6120.42 to 0.8931.0240.793 to 1.323
>180.8680.688 to 1.0941.0880.996 to 1.1870.9330.689 to 1.2650.5750.363 to 0.910.6720.519 to 0.869
Histological response
Good (<10% tumour)11111
Poor (≥10% tumour)1.7551.444 to 2.1335.8145.314 to 6.3613.8182.856 to 5.1042.0721.479 to 2.9041.0520.859 to 1.289
Time effect0.9860.985 to 0.987
Excision
Wide/radical111
Marginal0.7790.587 to 1.0331.0960.985 to 1.2190.8620.625 to 1.189
Intralesional2.0821.32 to 3.2851.2120.938 to 1.5664.0952.609 to 6.428
Location
Other11
Proximal femur/humerus1.6011.208 to 2.1231.4101.278 to 1.556
Axial10.8378.458 to 13.8850.7000.564 to 0.869
Sex
Female11111
Male0.9470.783 to 1.1451.0480.972 to 1.131.4021.079 to 1.820.7240.534 to 0.9821.3431.092 to 1.652
Volume
<20011111
≥2000.8020.642 to 1.0011.5131.397 to 1.6381.4991.152 to 1.9510.7550.502 to 1.1340.7600.592 to 0.975
  • Bold values indicate hazard ratios (HRs) with 95% confidence intervals (CIs) that exclude the null.