Amendments to the protocol
| Date | Change | Rationale |
| 29 January 2021 | Removed ‘Life expectancy/ total survival’ from the list of outcomes | After discussion within the team, we decided this outcome does not align well with the other included outcomes. The other outcomes give an indication of how well people self-manage their condition, whereas life expectancy/survival is a wider measure that gives less insight into self-management specifically. Moreover, there are unlikely to be many studies with sufficiently long follow-up to provide any meaningful assessment of survival in this context, and even if there was a study with very long follow-up, we would then be relying on an assumption that the patient activation exposures measured at baseline do not change over time. |