Characteristics of the study population
| Variable | Native oestrogen (control group) | Decreased oestrogen (group 1) | Augmented oestrogen (group 2) | P value | |
| Total N (%) | 11 923 (81.2) | 227 (1.5) | 2535 (17.3) | ||
| Deaths | No | 11 377 (95.4) | 204 (89.9) | 2481 (97.9) | <0.001 |
| Yes | 546 (4.6) | 23 (10.1) | 54 (2.1) | ||
| Age | Mean (SD) | 61.2 (8.3) | 64.4 (8.9) | 60.9 (7.7) | <0.001 |
| wCCI | Mean (SD) | 1.4 (2.4) | 5.0 (3.3) | 1.6 (2.5) | <0.001 |
| Income quintiles, n (%) | Richest | 3422 (28.7) | 64 (28.2) | 937 (37.0) | <0.001 |
| Rich | 2743 (23.0) | 42 (18.5) | 605 (23.9) | ||
| Middle | 2120 (17.8) | 35 (15.4) | 404 (15.9) | ||
| Poor | 1703 (14.3) | 47 (20.7) | 334 (13.2) | ||
| Poorest | 1903 (16.0) | 39 (17.2) | 253 (10.0) | ||
| Missing | 32 (0.3) | 0 (0) | 2 (0.1) | ||
| Education, n (%) | Tertiary | 4186 (35.1) | 82 (36.1) | 1074 (42.4) | <0.001 |
| Secondary | 5609 (47.0) | 97 (42.7) | 1150 (45.4) | ||
| Primary | 1882 (15.8) | 45 (19.8) | 290 (11.4) | ||
| Missing | 246 (2.1) | 3 (1.3) | 21 (0.8) |
wCCI, weighted Charlson Comorbidity Index.