PD simulation results
| Typical PD trial estimand | Alternative treatment policy estimand | |||
| PBO | Experimental | PBO | Experimental | |
| Primary endpoint OFF-time (hours), n | 250 | 250 | 250 | 250 |
| Mean (SE) | 5.28 (0.10) | 4.14 (0.10) | 4.90 (0.08) | 4.03 (0.08) |
| Mean difference (SE) experimental vs PBO | −1.14 (0.14) | −0.87 (0.12) | ||
| 95% CI | (−1.43 to –0.86) | (−1.11 to –0.64) | ||
| P value | <0.001 | <0.001 | ||
CI, confidence interval; n, sample size; PBO, placebo; PD, Parkinson’s disease; SE, standard error.