Table 5

Sensitivity and specificity (as percent), with 95% Cis. (in parentheses) of clinical signs of jaundice in neonates aged 1–20 days as assessed by physicians for detecting levels of hyperbilirubinaemia

SensitivitySpecificity
DhakaDelhiChandigarhDurbanKumasiLa PazDhakaDelhiChandigarhDurbanKumasiLa Paz
Serum bilirubin > 260 mmol/l (15 mg/dl)
(n=36)*(n=61)(n=39)(n=19)(n=17)(n=103)(n=46)(n=57)(n=340)(n=113)(n=53)(n=76)
Deep jaundice of the head53 (35 to 70)97
(89 to 100)
85
(69 to 94)
7 (54 to 94)55 (45 to 65)78
(64 to 89)
37
(24 to 51)
50
(44 to 55)
88
(80 to 93)
89
(80 to 95)
Deep jaundice of the trunk19
(8 to 36)
81
(69 to 90)
79
(64 to 91)
44
(20 to 70)
14
(8 to 23)
96
(85 to 99)
81
(68 to 90)
92
(89 to 95)
90
(82 to 95)
100
(95 to 100)
Any jaundice of the distal extremities56
(38 to 72)
66
(52 to 77)
38
(23 to 55)
42
(20 to 67)
59
(33 to 82)
11
(5 to 18)
80
(66 to 91)
95
(85 to 99)
97
(94 to 98)
93
(87 to 97)
74
(60 to 85)
99
(93 to 100)
Any jaundice of the distal extremities OR deep jaundice of the trunk56
(38 to 72)
90
(80 to 96)
79
(64 to 91)
47
(24 to 71)
15
(9 to 24)
80
(66 to 91)
79
(66 to 89)
91
(88 to 94)
87
(79 to 92)
99
(93 to 100)
Any jaundice of the distal extremities OR deep jaundice of the head or trunk64
(46 to 79)
98
(91 to 100)
85
(69 to 94)
79
(54 to 94)
55
(45 to 65)
74
(59 to 86)
37
(24 to 51)
49
(44 to 55)
83
(75 to 90)
88
(79 to 94)
Serum bilirubin > 340 mmol/l (20 mg/dl)
(n=14)†(n=26)(n=9)(n=2)‡(n=7)(n=36)(n=68)(n=92)(n=370)(n=130)(n=63)(n=143)
Deep jaundice of the head79 (49 to 95)100 (87 to 100)100
(66 to 100)
81
(64 to 92)
74
(61 to 83)
25
(16 to 35)
47
(42 to 53)
79
(71 to 86)
75
(67 to 82)
Deep jaundice of the trunk50
(23 to 77)
92
(75 to 99)
100
(66 to 100)
28
(14 to 45)
97
(90 to 100)
60
(50 to 70)
87
(83 to 90)
85
(77 to 91)
97
(92 to 99)
Any jaundice of the distal extremities86
(57 to 98)
85
(65 to 96)
78
(40 to 97)
71
(29 to 96)
17
(6 to 33)
75
(63 to 85)
77
(67 to 85)
95
(92 to 97)
88
(82 to 93)
70
(57 to 81)
96
(91 to 98)
Any jaundice of the distal extremities OR deep jaundice of the head or trunk86
(57 to 98)
100
(87 to 100)
100
(66 to 100)
28
(14 to 45)
75
(63 to 85)
55
(44 to 65)
86
(82 to 90)
82
(75 to 88)
95
(90 to 98)
Any jaundice of the distal extremities OR deep jaundice of the head or trunk93
(66 to 100)
100
(87 to 100)
100
(66 to 100)
81
(64 to 92)
68
(55 to 78)
24
(15 to 34)
47
(42 to 52)
75
(67 to 83)
74
(66 to 81)
  • *Numbers apply to serum bilirubin >260 mmol/L (15 mg/dL) for sites.

  • †Numbers apply to serum bilirubin >340 mmol/L (20 mg/dL) for sites.

  • ‡Both cases were found to have deep jaundice of the face, and one also had jaundice of palms and soles.