Database | Hypertension | n | 30-day outcomes, % (95% CI) | ||||||
VTE* | Death | Cardiac arrhythmia | Sepsis | ARDS | Intensive services | Total CVE† | |||
IQVIA-OpenClaims (USA) | With | 384 508 | 3.9 (3.8 to 4.0) | – | 15.4 (15.3 to 15.5) | 18.3 (18.2 to 18.4) | 34.8 (34.6 to 35.0) | 9.1 (9.0 to 9.2) | 11.3 (11.2 to 11.4) |
Without | 118 425 | 3.8 (3.7 to 3.9) | – | 7.2 (7.1 to 7.3) | 15.5 (15.3 to 15.7) | 31.3 (31.0 to 31.6) | 6.4 (6.3 to 6.5) | 4.5 (4.4 to 4.6) | |
OPTUM-HER (USA) | With | 18 242 | 6.2 (5.9 to 6.5) | 5.1 (4.8 to 5.4) | 31.6 (30.9 to 32.3) | 24.8 (24.2 to 25.4) | 45.7 (45.0 to 46.4) | 14.0 (13.5 to 14.5) | 18.2 (17.6 to 18.8) |
Without | 10 222 | 4.4 (4.0 to 4.8) | 1.6 (1.4 to 1.8) | 11.1 (10.5 to 11.7) | 15.0 (14.3 to 15.7) | 27.5 (26.6 to 28.4) | 6.3 (5.8 to 6.8) | 4.8 (4.4 to 5.2) | |
VA-OMOP (USA) | With | 8996 | 7.3 (6.8 to 7.8) | 15.4 (14.7 to 16.1) | 33.9 (32.9 to 34.9) | 20.0 (19.2 to 20.8) | 43.9 (42.9 to 44.9) | 17.1 (16.3 to 17.9) | 21.0 (20.2 to 21.8) |
Without | 1475 | 6.9 (5.6 to 8.2) | 7.6 (6.2 to 9.0) | 16.8 (14.9 to 18.7) | 16.2 (14.3 to 18.1) | 39.6 (37.1 to 42.1) | 11.2 (9.6 to 12.8) | 7.3 (6.0 to 8.6) | |
HealthVerity (USA) | With | 4512 | 3.6 (3.1 to 4.1) | – | 14.8 (13.8 to 15.8) | 16.5 (15.4 to 17.6) | 26.7 (25.4 to 28.0) | 6.1 (5.4 to 6.8) | 11.9 (11.0 to 12.8) |
Without | 3069 | 3.9 (3.2 to 4.6) | – | 6.8 (5.9 to 7.7) | 12.5 (11.3 to 13.7) | 23.9 (22.4 to 25.4) | 4.9 (4.1 to 5.7) | 5.6 (4.8 to 6.4) | |
SIDIAP (Spain) | With | 5636 | 1.0 (0.7 to 1.3) | 15.4 (14.5 to 16.3) | 0.5 (0.3 to 0.7) | – | 0.1 (0.0 to 0.2) | – | 0.9 (0.7 to 1.1) |
Without | 12 566 | 1.1 (0.9 to 1.3) | 10.9 (10.4 to 11.4) | 0.4 (0.3 to 0.5) | 0.0 (0.0 to 0.0) | 0.1 (0.0 to 0.2) | – | 0.5 (0.4 to 0.6) | |
CUIMC (USA) | With | 1708 | 3.9 (3.0 to 4.8) | 25.1 (23.0 to 27.2) | 12.1 (10.6 to 13.6) | 6.1 (5.0 to 7.2) | 16.0 (14.3 to 17.7) | 2.2 (1.5 to 2.9) | 8.1 (6.8 to 9.4) |
Without | 892 | 3.6 (2.4 to 4.8) | 10.2 (8.2 to 12.2) | 4.7 (3.3 to 6.1) | 5.3 (3.8 to 6.8) | 17.8 (15.3 to 20.3) | 1.8 (0.9 to 2.7) | 3.8 (2.5 to 5.1) | |
CU-AMC HDC (USA) | With | 904 | 11.4 (9.3 to 13.5) | 14.9 (12.6 to 17.2) | 45.8 (42.6 to 49.0) | 34.2 (31.1 to 37.3) | 65.6 (62.5 to 68.7) | 28.3 (25.4 to 31.2) | 19.8 (17.2 to 22.4) |
Without | 530 | 6.0 (4.0 to 8.0) | 6.0 (4.0 to 8.0) | 36.8 (32.7 to 40.9) | 27.4 (23.6 to 31.2) | 54.7 (50.5 to 58.9) | 15.5 (12.4 to 18.6) | 5.7 (3.7 to 7.7) | |
HIRA (South Korea) | With | 1943 | 0.7 (0.3 to 1.1) | 7.7 (6.5 to 8.9) | 4.4 (3.5 to 5.3) | 5.3 (4.3 to 6.3) | 2.6 (1.9 to 3.3) | 4.9 (3.9 to 5.9) | 10.0 (8.7 to 11.3) |
Without | 5656 | NC | 0.7 (0.5 to 0.9) | 0.7 (0.5 to 0.9) | 3.1 (2.6 to 3.6) | 0.5 (0.3 to 0.7) | 0.6 (0.4 to 0.8) | 4.7 (4.1 to 5.3) | |
STARR-OMOP (USA) | With | 342 | 2.0 (0.5 to 3.5) | 1.8 (0.4 to 3.2) | 22.2 (17.8 to 26.6) | 9.9 (6.7 to 13.1) | 12.6 (9.1 to 16.1) | 9.1 (6.1 to 12.1) | 16.4 (12.5 to 20.3) |
Without | 273 | NC | – | 6.6 (3.7 to 9.5) | 7.0 (4.0 to 10.0) | 11.4 (7.6 to 15.2) | 5.5 (2.8 to 8.2) | – | |
HMAR (Spain) | With | 594 | 3.2 (1.8 to 4.6) | 14.3 (11.5 to 17.1) | 23.1 (19.7 to 26.5) | 1.9 (0.8 to 3.0) | 12.6 (9.9 to 15.3) | 13.5 (10.8 to 16.2) | 12.1 (9.5 to 14.7) |
Without | 1417 | 2.6 (1.8 to 3.4) | 3.9 (2.9 to 4.9) | 6.6 (5.3 to 7.9) | 0.7 (0.3 to 1.1) | 7.3 (5.9 to 8.7) | 6.6 (5.3 to 7.9) | 2.2 (1.4 to 3.0) |
‘–’ means information is not available or <5 cases for all databases except for CU-AMC HDC, where information is not available for <10 cases.
*Venous thromboembolic (pulmonary embolism and deep vein thrombosis) events.
†Cardiovascular disease events (ischaemic stroke, haemorrhagic stroke, heart failure (heart failure during hospitalisation for the hospitalised cohort), acute myocardial infarction or sudden cardiac death).
ARDS, acute respiratory distress syndrome; CHARYBDIS, Characterizing Health Associated Risks and Your Baseline Disease In SARS-COV-2; CU-AMC-HDC, University of Colorado Anschutz Medical Campus Health Data Compass; CUIMC, Columbia University Irving Medical Center; HIRA, Health Insurance Review and Assessment Service; HMAR, Hospital del Mar; OMOP, Observational Medical Outcomes Partnership; OPTUM-HER, Optum de-identified Electronic Health Record Dataset; SIDIAP, Information System for Research in Primary Care; STARR, STAnford Medicine Research Data Repository; VA-OMOP, United States Department of Veterans Affairs.