Table 2

Characteristics of studies that met the inclusion criteria

Study designNo of articles n (%)No of patients N (%)
Case reports157 (88.7)219 (37.1)
Retrospective cohort studies10 (5.6)254 (43.1)
Prospective cohort studies5 (2.8)44 (7.5)
Case–control studies3 (1.7)36 (6.1)
Cross-sectional study1 (0.6)27 (4.6)
Prospective uncontrolled study1 (0.6)10 (1.7)
Total177 (100)590 (100)