Inclusion and exclusion criteria for participation in HESPER-HEALTH study
| Inclusion criteria | Exclusion criteria |
| Man or woman | Treated prediabetic or diabetic |
| 40–65 years (inclusive) | Treated for hypertension |
| Postmenopausal woman | Use of statins or other medications for lowering cholesterol |
| Overweight (waist circumference ≥80 cm for women and ≥94 cm for men, with BMI ≤30) | Treated with antibiotics, antifungals, probiotics or prebiotics in the 3 months before the enrolment |
| Menopausal hormone therapy | |
| Ability to give informed consent to participate in research. | Diagnosed gastrointestinal illness |
| Willingness to accept randomisation and undergo the testing and intervention procedures and deliver stool, blood and urine samples for testing | Any serious medical condition that precludes safe participation in the study |
| No aversion or intolerance to citrus foods | History of eating disorders |
| Accept to limit their total intake of flavonoid rich beverages (tea, coffee, cocoa, wine, fruit juice) to 250 mL/day | Digestive disorders with diarrhoea during the 3 months preceding the beginning of the study |
| Self-declared vegetarian, vegetarian, vegan | |
| History of substance or alcohol abuse | |
| Involvement in a weight loss programme within the three past months or who had a bariatric surgery | |
| Current smokers (within the last 30 days) | |
| Use of dietary supplements currently) or in the past 1 month | |
| Declarative strenuous exercise greater than 6 hours per week |
BMI, body mass index.