Risk factors for 30-day mortality
| Risk factor | Univariate analysis | Multivariable analysis | ||||
| OR | 95% CI | P value | OR* | 95% CI | P value | |
| Time from first prehospital contact to admission (intervals) | 1.26 | 1.07 to 1.47 | 0.01 | |||
| 0–6 hours | 1† | 1† | ||||
| 6–12 hours | 1.46 | 0.73 to 2.94 | 0.28 | 1.35 | 0.48 to 3.79 | 0.56 |
| 12–24 hours | 0.97 | 0.42 to 2.25 | 0.94 | 0.56 | 0.15 to 2.10 | 0.39 |
| >24 hours | 4.09 | 2.02 to 8.28 | <0.01 | 6.17 | 2.19 to 17.38 | <0.01 |
| No prehospital contact | 1.83 | 1.05 to 3.19 | 0.03 | 2.56 | 1.02 to 6.41 | 0.05 |
| Updated Charlson | 1.13 | 1.05 to 1.22 | <0.01 | 1.02 | 0.91 to 1.15 | 0.70 |
| Ambulance transport | 1.84 | 1.14 to 2.97 | 0.01 | 1.59 | 0.68 to 3.71 | 0.29 |
| Admission through ED | 0.55 | 0.29 to 1.03 | 0.06 | 1.35 | 0.43 to 4.25 | 0.61 |
| In SOFA score | 1.60 | 1.40 to 1.83 | <0.01 | 1.35 | 1.16 to 1.57 | <0.01 |
| Inappropriate empirical antibiotic therapy‡ | 3.92 | 1.64 to 9.33 | <0.01 | 5.50 | 1.62 to 18.63 | 0.01 |
| Rapid deterioration in general condition | 1.79 | 1.06 to 3.02 | 0.03 | 2.27 | 0.98 to 5.28 | 0.06 |
| Any care restrictions before or within 24 hours after admission | 9.95 | 5.95 to 16.64 | <0.01 | 10.37 | 4.96 to 21.67 | <0.01 |
| Matching | 1 | 0.99 to 1.00 | >0.99 | 1 | 0.99 to 1.0 | 0.20 |
P values <0.05 are shown in italics.
*Multivariable binomial regression analysis.
†Reference.
‡Clinical inappropriateness defined by local recommendations, suspected source of infection, severity of illness, dosage and correction for renal function.
ED, emergency department; SOFA, Sequential Organ Failure Assessment.